The authors explore sex-specific differences in the formation of fear memories across several rat brain regions.
Read More...Sex differences in linear polyubiquitination in the entorhinal cortex during fear memory formation
The authors explore sex-specific differences in the formation of fear memories across several rat brain regions.
Read More...Innovative Treatment for Reducing Senescence and Revitalizing Aging Cells through Gene Silencing
Cellular senescence plays a key role in aging cells and is attributed to a number of disease and pathology. These authors find that genetic editing of both RPS6KB1 and PPARGC1A revitalizes a human skin fibroblast cell line.
Read More...Characterization of Inflammatory Cytokine Gene Expression in a Family with a History of Psoriasis
Psoriasis is a heritable autoimmune disorder characterized by abnormal red and itchy skin patches. The authors study the family of a man with psoriasis. They explore whether the man's children, who do not show any symptoms of psoriasis, demonstrate gene expression consistent with the disease.
Read More...The Impacts of Varying Types of Light on the Growth of Five Arabidopsis Varieties
Arabadopsis, “the fruit fly of plants”, is an easy to grow plant system for genetic manipulation. Here, researchers tested the effects of varied light conditions on plants with specific mutations in the light sensing pathways.
Read More...Investigating the impact of electrocardiography biofeedback on POTS symptom management
The authors test electrocardiography biofeedback as a treatment for individuals with Postural Orthostatic Tachycardia Syndrome.
Read More...The effect of neuroinflammation and oxidative stress on the recovery time of seizures
Neuroinflammation and oxidative stress are both known to play a role in the occurrence and severity of seizures. This study tested effects of oxidative stress from seizures by evaluating the longevity, egg-laying, and electroshock resilience of C. elegans. Results revealed that oxidative stress and neuroinflammation diminish longevity and reproductivity while also increasing recovery time after seizures in C. elegans. This research can help lead to future studies and may also lead to finding new therapeutics for epilepsy.
Read More...Testing HCN1 channel dysregulation in the prefrontal cortex using a novel piezoelectric silk neuromodulator
Although no comprehensive characterization of schizophrenia exists, there is a general consensus that patients have electrical dysfunction in the prefrontal cortex. The authors designed a novel piezoelectric silk-based implant and optimized electrical output through the addition of conductive materials zinc oxide (ZnO) and aluminum nitride (AlN). With further research and compatibility studies, this implant could rectify electrical misfiring in the infralimbic prefrontal cortex.
Read More...Utilizing a Wastewater-Based Medium for Engineered Saccharomyces cerevisiae for the Biological Production of Fatty Alcohols and Carboxylic Acids to Replace Petrochemicals
Saccharomyces cerevisiae yeast is used to produce bioethanol, an alternative to fossil fuels. In this study, authors take advantage of this well studied yeast by genetically engineering them to increase fatty acid biosynthesis and culturing in a cost-effective wastewater based medium; potentially providing a sustainable alternative to petrochemicals.
Read More...The Protective Effects of Panax notoginseng Saponin on the Blood-Brain Barrier via the Nrf2/ARE Pathway in bEnd3 Cells
Disruption of the blood-brain barrier (BBB) is related to many neurological disorders, and can be caused by oxidative stress to cerebral microvascular endothelial cells (CMECs) composing the BBB. The authors of the paper investigated the protective effects of the total saponins in the leaves of Panax notoginseng (LPNS) on oxidative-stress-induced damage in a mouse cerebral microvascular endothelial cell line.
Read More...Emotional and Psychological Effect of Music on People
Nolt and Elwonger examine how different types of music impact our emotional and physical states. They found that music can influence a subject's emotional state, with sad music inspiring sadness and exciting music bringing excitement. They were not able to find a clear relationship between heart rate and music type. Music's effect on emotional state can be useful when designing novel therapies for emotional and mental disorders.
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