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Cytokine Treatment for Myocarditis May Directly Impact Cardiomyocytes Negatively

Kasner et al. | Apr 26, 2019

Cytokine Treatment for Myocarditis May Directly Impact Cardiomyocytes Negatively

The purpose of our study was to determine if direct administration of CXCL1/KC to cardiomyocytes causes negative changes to cell density or proliferation. This molecule has been shown to reduce inflammation in certain instances. Homocysteine models the direct effect of an inflammatory agent on cardiomyocytes. Our question was whether these molecules directly impact cell density through an interaction with the cell proliferation process. We hypothesized that cells treated with CXCL1/KC would maintain the same cell density as untreated cells. In contrast, cells treated with Homocysteine or both Homocysteine and CXCL1/KC, were expected to have a higher cell density that than that of untreated cells.

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Effect of Natural Compounds Curcumin and Nicotinamide on α-synuclein Accumulation in a C. elegans Model of Parkinson’s Disease

Mehrotra et al. | Jan 29, 2018

Effect of Natural Compounds Curcumin and Nicotinamide on α-synuclein Accumulation in a C. elegans Model of Parkinson’s Disease

Parkinson's disease is a neurodegenerative disorder that affects over 10 million people worldwide. It is caused by destruction of dopamine-producing neurons, which results in severe motor and movement symptoms. In this study, the authors investigated the anti-Parkinsonian effects of two natural compounds curcumin and nicotinamide using C. elegans as a model organism.

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The Emergence of Tetracycline Resistance in Rumen Bacteria

Memili et al. | Sep 16, 2016

The Emergence of Tetracycline Resistance in Rumen Bacteria

The emergence of antibiotic-resistant pathogenic bacteria is a major concern for human health, rendering some antibiotics ineffective in treating diseases. The authors of this study tested the hypothesis that exposing rumen bacteria to tetracycline will gradually lead to the development of tetracycline-resistant bacteria, some of which will develop multidrug resistance.

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The Clinical Accuracy of Non-Invasive Glucose Monitoring for ex vivo Artificial Pancreas

Levy et al. | Jul 10, 2016

The Clinical Accuracy of Non-Invasive Glucose Monitoring for <i>ex vivo</i> Artificial Pancreas

Diabetes is a serious worldwide epidemic that affects a growing portion of the population. While the most common method for testing blood glucose levels involves finger pricking, it is painful and inconvenient for patients. The authors test a non-invasive method to measure glucose levels from diabetic patients, and investigate whether the method is clinically accurate and universally applicable.

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Near-infrared activation of environmentally-friendly gold and silver nanoparticles for unclogging arteries

Gill et al. | Sep 06, 2024

Near-infrared activation of environmentally-friendly gold and silver nanoparticles for unclogging arteries

Coronary artery disease, the leading cause of death worldwide, results from cholesterol build-up in coronary arteries, limiting blood and oxygen flow to the heart. This study investigated the use of gold and silver nanoparticles coated with aspirin and activated by near-infrared light to improve blood flow in a clogged artery model. The nanoparticles increased simulated blood flow rates, demonstrating potential as a less invasive and more targeted treatment for cardiovascular disease.

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