Malaria is a major public health issue, especially in developing countries, and vector control is a major facet of malaria eradication efforts. Recently, sterile insect technique (SIT), or the release of sterile mosquitoes into the wild, has shown significant promise as a method of keeping vector populations under control. In this study, the authors investigate the Anopheles gambiae transglutaminase 3 protein (AgT3), which is essential to the mating of the Anopheles mosquito. They show that an active site mutation is able to abolish the activity of the AgT3 enzyme and propose it as a potential target for chemosterilant inhibitors.

Anticholinergics are used in treating asthma, a chronic inflammation of the airways. These drugs block human M1 and M2 muscarinic acetylcholine receptors, inhibiting bronchoconstriction. However, studies have reported complications of anticholinergic usage, such as exacerbated eosinophil production and worsened urinary retention. Modification of known anticholinergics using bioisosteric replacements to increase efficacy could potentially minimize these complications. The present study focuses on identifying viable analogs of anticholinergics to improve binding energy to the receptors compared to current treatment options. Glycopyrrolate (G), ipratropium (IB), and tiotropium bromide (TB) were chosen as parent drugs of interest, due to the presence of common functional groups within the molecules, specifically esters and alcohols. Docking score analysis via AutoDock Vina was used to evaluate the binding energy between drug analogs and the muscarinic acetylcholine receptors. The final results suggest that G-A3, IB-A3, and TB-A1 are the most viable analogs, as binding energy was improved when compared to the parent drug. G-A4, IB-A4, IB-A5, TB-A3, and TB-A4 are also potential candidates, although there were slight regressions in binding energy to both muscarinic receptors for these analogs. By researching the effects of bioisosteric replacements of current anticholinergics, it is evident that there is a potential to provide asthmatics with more effective treatment options.

In this manuscript the authors looked at current vaccine strategies against different strains of influenza. Looking at several factors they found that influenza strain as well as vaccinated age group, among other factors, impact vaccine effectiveness.

While 75% of waste in the United States is stated to be recyclable, only about 34% truly is. This project takes a stance to combat the pillars of mismanaged waste through a modern means of convenience: the TracedWaste app. The purpose of this study was to identify how individuals' waste disposal habits improved and knowledge increased (i.e. correctly disposing of waste, understanding negative incorrect waste disposal) due to their use of an informational waste management app as measured by a survey using a 1-5 Likert Scale. The results showed that the TracedWaste app helped conserve abundant resources such as energy and wood, decrease carbon emissions, and minimize financial toll all through reducing individual impact.

Inefficient penetration of cancer drugs into the interior of the three-dimensional (3D) tumor tissue limits drugs' delivery. The authors hypothesized that the addition of phospholipase A2 (PLA2) would increase the permeability of the drug doxorubicin for efficient drug penetration. They found that 1 mM PLA2 had the highest permeability. Increased efficiency in drug delivery would allow lower concentrations of drugs to be used, minimizing damage to normal cells.

In this article, the authors created CuSbS₂ solar cells. They discovered that the cells' efficiency was affected by the formation of MoS₂. By incorporating a layer of single-walled carbon nanotubes, however, they were able to prevent MoS₂ formation and increase the device's efficiency.

While serving as an immediate address for psychological safety and stability, psychological first aid (PFA) currently lacks the incorporation of triage. Without triage, patients cannot be prioritized in correspondence to condition severity that is often called for within emergency conditions. To disentangle the relevance of a potential triage system to PFA, the authors of this paper have developed a method to quantify resilience - a prominent predictor of the capability to recover from a disaster. With this resilience index, they have quantified resilience of differing age, race, and sex demographics to better inform the practice of PFA and potential demographic prioritization via a triage system.

There is limited evidence that extended exposure to an electromagnetic field (EMF) has negative health effects on humans. The authors measured the power density and strength of EMF at different distances and directions in front of a microwave oven, and they discuss the safety of different distances.

Based on the success of deep learning, recent works have attempted to develop a waste classification model using deep neural networks. This work presents federated learning (FL) for a solution, as it allows participants to aid in training the model using their own data. Results showed that with less clients, having a higher participation ratio resulted in less accuracy degradation by the data heterogeneity.

Disruption of the blood-brain barrier (BBB) is related to many neurological disorders, and can be caused by oxidative stress to cerebral microvascular endothelial cells (CMECs) composing the BBB. The authors of the paper investigated the protective effects of the total saponins in the leaves of Panax notoginseng (LPNS) on oxidative-stress-induced damage in a mouse cerebral microvascular endothelial cell line.