Supernovas are powerful explosions that result from gravitational collapse of a massive star. Using photometric analysis Arora et al. set out to investigate whether 2020pni (located in galaxy UGC 9684) was a supernova. They were ultimately able to identify 2020pni as a Type II-L supernova and determine it's distance from earth.

Recently, e-cigarette usage has been increasing rapidly. Previous research has found that adverse
childhood experiences (ACEs) are correlated to cigarette usage. However, there is limited data exploring if ACEs affect vaping. Therefore, in this work, we investigated the effects of ACEs on e-cigarette usage and hypothesize that witnessing vaping in the house and facing ACEs would increase e-cigarette usage while education on the dangers of vaping would decrease e-cigarette usage. We found that different types of ACEs had different correlations with e-cigarette usage and that education on the dangers of vaping had no effect on e-cigarette usage.

Using a convolution neural network, these authors show machine learning can clinically diagnose breast cancer with high accuracy.

Cellular senescence plays a key role in aging cells and is attributed to a number of disease and pathology. These authors find that genetic editing of both RPS6KB1 and PPARGC1A revitalizes a human skin fibroblast cell line.

Here, beginning from an initial interest in the possibility to use a computer to automatically solve a geometry diagram parser, the authors developed their own Fast Geometry Diagram Parser (FastGDP) that uses clustering and corner information. They compared their own methods to a more widely available, method, GeoSolver, finding their own to be an order of magnitude faster in most cases that they considered.

Staphylococcus aureus is a major pathogen in both hospitals and the community and can cause systemic infections such as pneumonia. Multi-drug resistant strains, such as Methicillin-resistant S. aureus (MRSA) are particularly worrisome. In order to reduce the development of bacterial resistance, we hypothesized that two selected traditional Chinese medicines, Shuang-Huang-Lian (SHL) and Lan-Qin, would be effective against S. aureus. The results showed that SHL had a synergistic effect with gentamicin as well as additive effects with penicillin and cefazolin against S. aureus compared with using antibiotics alone.

Pillai et al. look at whether exposure to Schistosoma mansoni, a parasitic blood fluke, has any relation to peanut allergies. They found that cockroaches exposed to an antigen found in S. mansoni eggs exhibited an allergic reaction to peanuts.

Glioblastoma Multiforme (GBM) is the most malignant brain tumor with the highest fraction of genome alterations (FGA), manifesting poor disease-free status (DFS) and overall survival (OS). We explored The Cancer Genome Atlas (TCGA) and cBioportal public dataset- Firehose legacy GBM to study DNA repair genes Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) and Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3 (ALKBH3). To test our hypothesis that these genes have correlations with FGA and can better determine prognosis and survival, we sorted the dataset to arrive at 254 patients. Analyzing using RStudio, both ASCC3 and ALKBH3 demonstrated hypomethylation in 82.3% and 61.8% of patients, respectively. Interestingly, low mRNA expression was observed in both these genes. We further conducted correlation tests between both methylation and mRNA expression of these genes with FGA. ASCC3 was found to be negatively correlated, while ALKBH3 was found to be positively correlated, potentially indicating contrasting dysregulation of these two genes. Prognostic analysis showed the following: ASCC3 hypomethylation is significant with DFS and high ASCC3 mRNA expression to be significant with OS, demonstrating ASCC3’s potential as disease prediction marker.

There have been several issues concerning the water quality in Ulaanbaatar, Mongolia in the past few years. This study, we collected 28 samples from 6 districts of Ulaanbaatar to check if the water supply quality met the standards of the World Health Organization, the Environmental Protection Agency, and a Mongolian National Standard. Only three samples fully met all the requirements of the global standards. Samples in Zaisan showed higher hardness (>120 ppm) and alkalinity levels (20–200 ppm) over the other districts in the city. Overall, the results show that it is important to ensure a safe and accessible water supply in Ulaanbaatar to prevent future water quality issues.

Over the last few decades, childhood stunting has persisted as a major global challenge. This study hypothesized that TPTO (Tree-based Pipeline Optimization Tool), an AutoML (automated machine learning) tool, would outperform all pre-existing machine learning models and reveal the positive impact of economic prosperity, strong familial traits, and resource attainability on reducing stunting risk. Feature correlation plots revealed that maternal height, wealth indicators, and parental education were universally important features for determining stunting outcomes approximately two years after birth. These results help inform future research by highlighting how demographic, familial, and socio-economic conditions influence stunting and providing medical professionals with a deployable risk assessment tool for predicting childhood stunting.