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The Protective Antioxidant Effects of Sulforaphane on Germinating Radish Seeds Treated with Hydrogen Peroxide

Dasuri et al. | Feb 19, 2021

The Protective Antioxidant Effects of Sulforaphane on Germinating Radish Seeds Treated with Hydrogen Peroxide

Free radical chain reactions result when atoms containing unpaired electrons bind with biomolecules and alter their biological functions, contributing to the progression of diseases such as atherosclerosis, cancer, and diabetes. Antioxidants, such as vitamin E and sulforaphane, are effective neutralizers of free radicals and prevent cellular damage. This present study is conducted to determine the relative effectiveness of sulforaphane against free radicals generated by hydrogen peroxide (H2O2) compared with the known antioxidant vitamin E.

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Utilizing 25-Hydroxyvitamin D3 to prevent the appearance of diabetic-like phenotypes in Drosophila melanogaster

Zaverchand et al. | Sep 20, 2021

Utilizing 25-Hydroxyvitamin D3 to prevent the appearance of diabetic-like phenotypes in Drosophila melanogaster

This study aimed to assess the role of 25-hydroxyvitamin D3 solution, at varying concentrations, in protecting vertical transmission of diabetic-like phenotypes. We hypothesized that the highest concentration of vitamin D solution (55 ng/mL) would be most effective in having a protective role. The results indicated that the hypothesis was partially supported; overall, all three concentrations of the vitamin D solution administered to the flies reared on HSDs had a protective effect, to varying extents.

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Reactivity-informed design, synthesis, and Michael addition kinetics of C-ring andrographolide analogs

Zhou et al. | Nov 17, 2022

Reactivity-informed design, synthesis, and Michael addition kinetics of C-ring andrographolide analogs

Here, based on the identification of androgapholide as a potential therapeutic treatment against cancer, Alzheimer's disease, diabetes, and multiple sclerosis, due to its ability to inhibit a signaling pathway in immune system function, the authors sought ways to optimize the natural product human systems by manipulating its chemical structure. Through the semisynthesis of a natural product along with computational studies, the authors developed an understanding of the kinetic mechanisms of andrographolide and semisynthetic analogs in the context of Michael additions.

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Effect of hypervitaminosis A in regenerating planaria: A potential model for teratogenicity testing

Bennet et al. | Dec 12, 2022

Effect of hypervitaminosis A in regenerating planaria: A potential model for teratogenicity testing

This unique research study evaluated the potential use of the flatworm, brown planaria (Dugesia tigrine), as an alternative model for teratogenicity testing. In this study, we exposed amputated planaria to varying concentrations of a known teratogen, vitamin A (retinol), for approximately 2 weeks, and evaluated multiple parameters including the formation of blastema and eyes. The results from this study demonstrated that high concentrations of retinol caused defects in head and eye formation in regenerating planaria, with similarities to vitamin A related teratogenicity findings in mammals. Based on these results, regenerating brown planaria are a promising alternative model for teratogenicity testing, which can potentially be paradigm shifting as it can reduce cost, time, and pregnant animal use in research.

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Albuterol extends lifespan of Caenorhabditis elegans

Belkin et al. | Oct 19, 2021

Albuterol extends lifespan of <i>Caenorhabditis elegans</i>

The objective of this experiment is to determine if the medication albuterol has a positive impact on the lifespan of C. elegans. We hypothesize that if albuterol is added to the diet of C. elegans, then the lifespan of C. elegans will increase. Albuterol increased the mean lifespan of C. elegans by 4.31 ± 0.13 days, compared to the control group and increased the outer range of the C. elegans lifespan. The method of which this occurred is still unknown.

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The effect of wild orange essential oil on ascorbic acid decay in freshly squeezed orange juice

Sebek et al. | Feb 25, 2022

The effect of wild orange essential oil on ascorbic acid  decay in freshly squeezed orange juice

The goal of this project was to see if the addition of wild orange essential oil to freshly squeezed orange juice would help to slow down the decay of ascorbic acid when exposed to various temperatures, allowing vital nutrients to be maintained and providing a natural alternative to the chemical additives in use in industry today. The authors hypothesized that the addition of wild orange essential oil to freshly squeezed orange juice would slow down the rate of oxidation when exposed to various temperatures, reducing ascorbic acid decay. On average, wild orange EO slowed down ascorbic acid decay in freshly squeezed orange juice by 15% at the three highest temperatures tested.

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Comparing the Dietary Preference of Caenorhabditis elegans for Bacterial Probiotics vs. Escherichia coli.

Lulla et al. | Dec 18, 2020

Comparing the Dietary Preference of <i>Caenorhabditis elegans</i> for Bacterial Probiotics vs. <i>Escherichia coli</i>.

In this experiment, the authors used C. elegans as a simple model organism to observe the impact of probiotics on the human digestive system. The results of the experiments showed that the C. elegans were, on average, most present in Chobani cultures over other tested yogurts. While not statistically significant, these results still demonstrated that C. elegans might prefer Chobani cultures over other probiotic yogurts, which may also indicate greater gut benefits from Chobani over the other yogurt brands tested.

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Identification of a Free Radical Scavenger as an Additive for Lung Transplant Preservation Solution to Inhibit Coagulative Necrosis and Extend Organ Preservation

Ganesh et al. | Feb 12, 2015

Identification of a Free Radical Scavenger as an Additive for Lung Transplant Preservation Solution to Inhibit Coagulative Necrosis and Extend Organ Preservation

During transfer of organs from a donor to a patient, the organs deteriorate in part due to damage by free radicals. Application of antioxidant solutions could extend organ preservation times. The authors found that vitamin E and butylated hydroxytoluene seemed to be most effective in arresting cell damage of a bovine lung.

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