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Testing the Effects of Resveratrol, Apigenin, and Glucosamine to Effectively Reduce Prostate Cancer Cell Proliferation, Migration Levels, and Increase Apoptosis

Yang et al. | Apr 16, 2020

Testing the Effects of Resveratrol, Apigenin, and Glucosamine to Effectively Reduce Prostate Cancer Cell Proliferation, Migration Levels, and Increase Apoptosis

The current five-year survival rate of metastasized prostate cancer is only 30% and occurs in every one in nine men. Researchers have shown that people with a type of dwarfism called Laron’s Syndrome are immune to cancer due to their low levels of insulin-like growth factor-1 (IGF-1). For this reason, experimentally modifying the level of IGF-1 could provide better insight into whether lowering the levels of IGF-1 in prostate cancer cell lines (e.g. PC-3) could be an effective treatment to reduce their rates of proliferation and migration and increase apoptosis. We selected three compounds, which researchers have shown decrease IGF-1 levels, to test and combine to determine which is the most promising.

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Herbal Extracts Alter Amyloid Beta Levels in SH-SY5Y Neuroblastoma Cells

Xu et al. | Feb 25, 2020

Herbal Extracts Alter Amyloid Beta Levels in SH-SY5Y Neuroblastoma Cells

Alzheimer’s disease (AD) is a type of dementia that affects more than 5.5 million Americans, and there are no approved treatments that can delay the advancement of the disease. In this work, Xu and Mitchell test the effects of various herbal extracts (bugleweed, hops, sassafras, and white camphor) on Aβ1-40 peptide levels in human neuroblastoma cells. Their results suggest that bugleweed may have the potential to reduce Aβ1-40 levels through its anti-inflammatory properties.

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Development of a Novel Treatment Strategy to Treat Parkinsonian Neurodegeneration by Targeting Both Lewy Body Aggregation and Dopaminergic Neuronal Degradation in a Drosophila melanogaster Model

Sama et al. | Sep 25, 2019

Development of a Novel Treatment Strategy to Treat Parkinsonian Neurodegeneration by Targeting Both Lewy Body Aggregation and Dopaminergic Neuronal Degradation in a <em>Drosophila melanogaster</em> Model

In this article the authors address the complex and life quality-diminishing neurodegenerative disease known as Parkinson's. Although genetic and/or environmental factors contribute to the etiology of the disease, the diagnostic symptoms are the same. By genetically modifying fruit flies to exhibit symptoms of Parkinson's disease, they investigate whether drugs that inhibit mitochondrial calcium uptake or activate the lysosomal degradation of proteins could improve the symptoms of Parkinson's these flies exhibit. The authors report the most promising outcome to be that when both types of drugs were used together. Their data provides encouraging evidence to support further investigation of the utility of such drugs in the treatment of human Parkinson's patients.

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A Novel Alzheimer's Disease Therapeutic Model: Attenuating Hyperphosphorylated Tau and Amyloid β (Aβ) Aggregates by Characterizing Antioxidative, Anti-Inflammatory, and Neuroprotective Properties of Natural Extracts

Pokkunuri et al. | Jul 25, 2022

A Novel Alzheimer's Disease Therapeutic Model: Attenuating Hyperphosphorylated Tau and Amyloid β (Aβ) Aggregates by Characterizing Antioxidative, Anti-Inflammatory, and Neuroprotective Properties of Natural Extracts

Oxidative damage and neuro-inflammation were the key pathways implicated in the pathogenesis of Alzheimer’s disease. In this study, 30 natural extracts from plant roots and leaves with extensive anti-inflammatory and anti-oxidative properties were consumed by Drosophila melanogaster. Several assays were performed to evaluate the efficacy of these combinational extracts on delaying the progression of Alzheimer’s disease. The experimental group showed increased motor activity, improved associative memory, and decreased lifespan decline relative to the control group.

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Effects on Learning and Memory of a Mutation in Dα7: A D. melanogaster Homolog of Alzheimer's Related Gene for nAChR α7

Sanyal et al. | Oct 01, 2019

Effects on Learning and Memory of a Mutation in Dα7: A <em>D. melanogaster</em> Homolog of Alzheimer's Related Gene for nAChR α7

Alzheimer's disease (AD) involves the reduction of cholinergic activity due to a decrease in neuronal levels of nAChR α7. In this work, Sanyal and Cuellar-Ortiz explore the role of the nAChR α7 in learning and memory retention, using Drosophila melanogaster as a model organism. The performance of mutant flies (PΔEY6) was analyzed in locomotive and olfactory-memory retention tests in comparison to wild type (WT) flies and an Alzheimer's disease model Arc-42 (Aβ-42). Their results suggest that the lack of the D. melanogaster-nAChR causes learning, memory, and locomotion impairments, similar to those observed in Alzheimer's models Arc-42.

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Examining effects of E. muscae on olfactory function in D. melanogaster

Friedman et al. | Jul 08, 2021

Examining effects of <em>E. muscae</em> on olfactory function in <em>D. melanogaster</em>

In this article, the authors investigate the effects of fungus E. muscae on fruit fly behavior. More specifically, they investigate whether this fungus affects olfaction. Their findings contribute to a broader set of studies seeking to understand how host's central nervous systems can be affected by infections.

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Can the Growth Mindset Encourage Girls to Pursue “Male” Careers?

Lateef et al. | Oct 03, 2021

Can the Growth Mindset Encourage Girls to Pursue “Male” Careers?

Despite major advances in gender equality, men still far outnumber women in science, technology, engineering and math (STEM) professions. The purpose of this project was to determine whether mindset could affect a student’s future career choices and whether this effect differed based on gender. When looking within the gender groups, 86% of females who had a growth mindset were likely to consider a “male” career, whereas only 16% of females with fixed mindset would likely to consider a “male” career. Especially for girls, cultivating a growth mindset may be a great strategy to address the problem of fewer girls picking STEM careers.

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Presoaking Seeds with Vinegar Improves Seed Development and Drought Tolerance in Maize Plants

D'Agate et al. | Jul 24, 2020

Presoaking Seeds with Vinegar Improves Seed Development and Drought Tolerance in Maize Plants

Climate change has contributed to the increasing annual temperatures around the world and poses a grave threat to Maize crops. Two methods proven to help combat plant drought stress effects are presoaking seeds (seeds are soaked in a liquid before planting) and the application of Acetic Acid (vinegar) to soil. The purpose of this experiment was to explore if combining these two methods by presoaking seeds with a vinegar solution can improve the seed development and plant drought tolerance of Maize plants during drought conditions.

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A Quantitative Analysis of the Proliferation of Microplastics in Williamston’s Waterways

Schafer et al. | Feb 17, 2019

A Quantitative Analysis of the Proliferation of Microplastics in Williamston’s Waterways

Plastic debris can disrupt marine ecosystems, spread contaminants, and take years to naturally degrade. In this study, Wu et al aim to establish an understanding of the scope of Williamston, Michigan’s microplastics problem, as well as to attempt to find the source of these plastics. Initially, the authors hypothesize that the Williamston Wastewater Treatment Plant was the primary contributor to Williamston’s microplastics pollution. Although they find a general trend of increasing concentrations of microplastics from upstream to downstream, they do not pinpoint the source of Williamston’s microplastics pollution in the present research.

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FCRL3 Gene Association with Asthma and Allergic Rhinitis

Sheikh et al. | Aug 05, 2020

FCRL3 Gene Association with Asthma and Allergic Rhinitis

This study sought to determine if there is an association between the single nucleotide polymorphism rs7528684 of the Fc receptor-like-3 (FCRL3) gene and asthma or allergic rhinitis (AR). Based on previous studies in an Asian population, we hypothesized that participants with an AA genotype of FCRL3 would be more likely to have asthma and/or allergic rhinitis. To test the hypothesis, surveys were administered to participants, and genotyping was performed on spit samples via PCR, restriction digest, and gel electrophoresis.

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