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The effect of Omega-3 on bovine blood cells as a potential remedy for Cerebral Cavernous Malformations

Pulluru et al. | Sep 22, 2023

The effect of Omega-3 on bovine blood cells as a potential remedy for Cerebral Cavernous Malformations
Image credit: Carolien van Oijen

Here, the authors investigated if dietary Omega-3 fatty acids could reduce the potential for cerebral cavernous malformations, which are brain lesions that occur due to a genetic mutation where high membrane permeability occurs between endothelial cell junctions. In a bovine-based study where some cows were fed an Omega-3 diet, the authors found the membranes of bovine blood cells increased in thickness with Omega-3 supplementation. As a result, they suggest that dietary Omega-3 could be considered as a possible preventative measure for cerebral cavernous malformations.

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Computational Structure-Activity Relationship (SAR) of Berberine Analogs in Double-Stranded and G-Quadruplex DNA Binding Reveals Both Position and Target Dependence

Sun et al. | Dec 18, 2020

Computational Structure-Activity Relationship (SAR) of Berberine Analogs in Double-Stranded and G-Quadruplex DNA Binding Reveals Both Position and Target Dependence

Berberine, a natural product alkaloid, and its analogs have a wide range of medicinal properties, including antibacterial and anticancer effects. Here, the authors explored a library of alkyl or aryl berberine analogs to probe binding to double-stranded and G-quadruplex DNA. They determined that the nature of the substituent, the position of the substituent, and the nucleic acid target affect the free energy of binding of berberine analogs to DNA and G-quadruplex DNA, however berberine analogs did not result in net stabilization of G-quadruplex DNA.

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Effect of Different Growth Media on Algae’s Ability for Carbon Dioxide Biofixation

Chaudhuri et al. | Oct 12, 2020

Effect of Different Growth Media on Algae’s Ability for Carbon Dioxide Biofixation

In this study, the authors investigate the effects of different algal growth media on algae's ability to perform carbon dioxide biofixation, or utilize carbon dioxide by fixing it into fatty acids within the cells. More specifically, carbon dioxide biofixation of Chlorella vulgaris was cultured in one of four media options and carbon dioxide was measured and compared to controls. The study results demonstrated that the use of media can enhance algae's capacity for biofixation and this has important implications for developing methods to reduce carbon dioxide in the environment.

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Phospholipase A2 increases the sensitivity of doxorubicin induced cell death in 3D breast cancer cell models

Lee et al. | Mar 30, 2022

Phospholipase A2 increases the sensitivity of doxorubicin induced cell death in 3D breast cancer cell models

Inefficient penetration of cancer drugs into the interior of the three-dimensional (3D) tumor tissue limits drugs' delivery. The authors hypothesized that the addition of phospholipase A2 (PLA2) would increase the permeability of the drug doxorubicin for efficient drug penetration. They found that 1 mM PLA2 had the highest permeability. Increased efficiency in drug delivery would allow lower concentrations of drugs to be used, minimizing damage to normal cells.

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Effects of Ocean Acidification on Marine Calcium Carbonate

Prahalad et al. | Jul 31, 2020

Effects of Ocean Acidification on Marine Calcium Carbonate

Industrialization has transformed human life and improved it for many. Nonetheless, a side effect has been an increase in chemical waste, which when not disposed of properly, has detrimental effects on surrounding habitats. An increase in ocean acidification could potentially affect many forms of life, disrupting the ecological balance in unforeseeable ways. In this article the authors explore the effect of acidification on corals and shells, and observe that an increase in ocean acidity has a significant effect on corals, but not shells. This illustrates how acidification could negatively affect marine life, and calls our attention to managing the factors that contribute to increasing the pH of the Earth's water bodies.

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The determinants and incentives of corporate greenhouse gas emission reduction

Liu et al. | Jun 04, 2021

The determinants and incentives of corporate greenhouse gas emission reduction

This study used hand-collected Greenhouse gas (GHG) emissions data from the Environmental Protection Agency (EPA) and aimed to understand the determinants and incentives of GHG emissions reduction. It explored how companies’ financials, Chief Executive Officer (CEO) compensation, and corporate governance affected GHG emissions. Results showed that companies reporting GHG emissions were wide-spread among the 48 industries represented by two-digit Standard Industrial Classification (SIC) codes.

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