The authors looked at how pharmacokinetics changed depending on the use of an in vitro or an in vivo model.
Read More...In vitro dissolution and in vivo response of pseudoephedrine dosage forms
The authors looked at how pharmacokinetics changed depending on the use of an in vitro or an in vivo model.
Read More...Silver nanoparticle-coated orthopedic screws lead to greater calcium precipitation
The authors test whether coating stainless steel orthopedic screws in silver will promote calcium precipitation to improve orthopedic implant integration into bone.
Read More...Mendelian randomization reveals shared genetic landscape in autism spectrum disorder and Alzheimer's disease
Autism Spectrum Disorder (ASD) and Alzheimer's Disease (AD) are distinct conditions, but research suggests a link, as individuals with ASD are 2.5 times more likely to develop AD. A study employing genome-wide association studies and Mendelian randomization revealed shared genetic factors, particularly in synaptic regulation pathways, that may increase the risk of AD in those with ASD. These findings provide insights into the genetic underpinnings connecting the two disorders.
Read More...SOS-PVCase: A machine learning optimized lignin peroxidase with polyvinyl chloride (PVC) degrading properties
The authors looked at the primary structure of lignin peroxidase in an attempt to identify mutations that would improve both the stability and solubility of the peroxidase protein. The goal is to engineer peroxidase enzymes that are stable to help break down polymers, such as PVC, into monomers that can be reused instead of going to landfills.
Read More...Digestion products of bread and cheese cause addictive behavior in a planaria model
The authors looked at two peptides, gluteomorphin and casomorphin, that are present after the digestion of bread and cheese. As these peptides can bind opioid receptors the authors want to know if they could be addictive in the same way as conventional opioids (i.e., morphine) are known to be. Their results in a planaria model suggest that both of these peptides are addictive.
Read More...Intra and interspecies control of bacterial growth through extracellular extracts
The study discusses the relationship between bacterial species and the human gut microbiome, emphasizing the role of quorum sensing molecules in bacterial communication and its implications for health. Authors investigated the impact of bacterial supernatants from Escherichia coli (E. coli) on the growth of new E. coli and Enterobacter aerogenes (E. aerogenes) cultures.
Read More...The frequency and psychological effects of name mispronunciation in an independent school
The authors survey high school students regarding the frequency of microaggressions such as name mispronunciation.
Read More...A novel approach for predicting Alzheimer’s disease using machine learning on DNA methylation in blood
Here, recognizing the difficulty associated with tracking the progression of dementia, the authors used machine learning models to predict between the presence of cognitive normalcy, mild cognitive impairment, and Alzheimer's Disease, based on blood DNA methylation levels, sex, and age. With four machine learning models and two dataset dimensionality reduction methods they achieved an accuracy of 53.33%.
Read More...Analysis of ultraviolet light as a bactericide of gram-negative bacteria in Cladophora macroalgae extracts
Here, the authors sought to use Cladophora macroalgae as a possible antibiotic to address the growing threat of antibiotic resistance in pathogenic bacteria. However, when they observed algae extracts to be greatly contaminated with gram-negative bacteria, they adapted to explore the ability to use ultraviolet light as a bactericide. They found that treatment with ultraviolet light had a significant effect.
Read More...A Crossover Study Comparing the Effect of a Processed vs. Unprocessed Diet on the Spatial Learning Ability of Zebrafish
The authors compared the short-term effects of processed versus unprocessed food on spatial learning and survival in zebrafish, given the large public concern regarding processed foods. By randomly assigning zebrafish to a diet of brine shrimp flakes (processed) or live brine shrimp (unprocessed), the authors show while there is no immediate effect on a fish's decision process between the two diets, there are significant correlations between improved learning and stress response with the unprocessed diet.
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