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Pancreatic Adenocarcinoma: An Analysis of Drug Therapy Options through Interaction Maps and Graph Theory

Gupta et al. | Feb 04, 2014

Pancreatic Adenocarcinoma: An Analysis of Drug Therapy Options through Interaction Maps and Graph Theory

Cancer is often caused by improper function of a few proteins, and sometimes it takes only a few proteins to malfunction to cause drastic changes in cells. Here the authors look at the genes that were mutated in patients with a type of pancreatic cancer to identify proteins that are important in causing cancer. They also determined which proteins currently lack effective treatment, and suggest that certain proteins (named KRAS, CDKN2A, and RBBP8) are the most important candidates for developing drugs to treat pancreatic cancer.

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DyGS: A Dynamic Gene Searching Algorithm for Cancer Detection

Wang et al. | Jun 05, 2018

DyGS: A Dynamic Gene Searching Algorithm for Cancer Detection

Wang and Gong developed a novel dynamic gene-searching algorithm called Dynamic Gene Search (DyGS) to create a gene panel for each of the 12 cancers with the highest annual incidence and death rate. The 12 gene panels the DyGS algorithm selected used only 3.5% of the original gene mutation pool, while covering every patient sample. About 40% of each gene panel is druggable, which indicates that the DyGS-generated gene panels can be used for early cancer detection as well as therapeutic targets in treatment methods.

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Expressional correlations between SERPINA6 and pancreatic ductal adenocarcinoma-linked genes

Selver et al. | Oct 06, 2021

Expressional correlations between <em>SERPINA6</em> and pancreatic ductal adenocarcinoma-linked genes

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer, with early diagnosis and treatment challenges. When any of the genes KRAS, SMAD4, TP53, and BRCA2 are heavily mutated, they correlate with PDAC progression. Cellular stress, partly regulated by the gene SERPINA6, also correlates with PDAC progression. When SERPINA6 is highly expressed, corticosteroid-binding globulin inhibits the effect of the stress hormone cortisol. In this study, the authors explored whether there is an inverse correlation between the expression of SERPINA6 and PDAC-linked genes.

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Fluorescein or Green Fluorescent Protein: Is It Possible to Create a Sensor for Dehydration?

Joshi et al. | Dec 09, 2019

Fluorescein or Green Fluorescent Protein: Is It Possible to Create a Sensor for Dehydration?

Currently there is no early dehydration detection system using temperature and pH as indicators. A sensor could alert the wearer and others of low hydration levels, which would normally be difficult to catch prior to more serious complications resulting from dehydration. In this study, a protein fluorophore, green fluorescent protein (GFP), and a chemical fluorophore, fluorescein, were tested for a change in fluorescence in response to increased temperature or decreased pH. Reversing the pH change did not restore GFP fluorescence, but that of fluorescein was re-established. This finding suggests that fluorescein could be used as a reusable sensor for a dehydration-related pH change.

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Development of Two New Efficient Means of Wastewater Treatment

Bao et al. | Feb 06, 2014

Development of Two New Efficient Means of Wastewater Treatment

The water we use must be treated and cleaned before we release it back into the environment. Here, the authors investigate two new techniques for purifying dissolved impurities from waste water. Their findings may give rise to more cheaper and more efficient water treatment and help keep the planet greener.

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Comparing the Effectiveness of Popular Treatments for Swelling and Scarring

Benavides et al. | Jul 08, 2020

Comparing the Effectiveness of Popular Treatments for Swelling and Scarring

Numerous specialty treatments claim to reduce swelling and scarring; however, it is unknown if these treatments are more effective than less expensive treatments. In an attempt to determine if one outperforms the other, treatments were applied to the same subject following bilateral orthopedic foot surgery. No difference was found the specialty treatments compared to more cost-effective treatments.

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The Effects of Antibiotics on Nutrient Digestion

Murea et al. | Oct 06, 2017

The Effects of Antibiotics on Nutrient Digestion

One disadvantage of antibiotic therapy is the potential for unpleasant gastrointestinal side effects. Here, the authors test whether some common antibiotics directly interfere with the digestion of protein, fat, or sugars. This study provides motivation to more carefully investigate the interactions between antibiotics and gut enzymes in order to inform treatment decisions and improve patient outcomes.

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Ant Colony Optimization Algorithms with Multiple Simulated Colonies Offer Potential Advantages for Solving the Traveling Salesman Problem and, by Extension, Other Optimization Problems

Wildenhain et al. | May 22, 2015

Ant Colony Optimization Algorithms with Multiple Simulated Colonies Offer Potential Advantages for Solving the Traveling Salesman Problem and, by Extension, Other Optimization Problems

Ant colony optimization algorithms simulate ants moving from point to point on a graph and coordinate their actions, similar to ants laying down pheromones to strengthen a path as it is used more frequently. These ACO algorithms can be applied to the classic traveling salesman problem, which aims to determine the lowest-cost path through a given set of points on a graph. In this study, a novel multiple-colony system was developed that uses multiple simulated ant colonies to generate improved solutions to the traveling salesman problem.

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