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Effect of Natural Compounds Curcumin and Nicotinamide on α-synuclein Accumulation in a C. elegans Model of Parkinson’s Disease

Mehrotra et al. | Jan 29, 2018

Effect of Natural Compounds Curcumin and Nicotinamide on α-synuclein Accumulation in a C. elegans Model of Parkinson’s Disease

Parkinson's disease is a neurodegenerative disorder that affects over 10 million people worldwide. It is caused by destruction of dopamine-producing neurons, which results in severe motor and movement symptoms. In this study, the authors investigated the anti-Parkinsonian effects of two natural compounds curcumin and nicotinamide using C. elegans as a model organism.

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Qualitative tracking of human and animation motions reveals differences in their walking gaits

Baily et al. | Oct 04, 2024

Qualitative tracking of human and animation motions reveals differences in their walking gaits

In their attempt to evoke a greater emotional connection with viewers, animators have strived to replicate human movements in their animations. However, animation movements still appear distinct from human movements. With a focus on walking, we hypothesized that animations, unaffected by real external forces (e.g. gravity), would move with a universally distinct, gliding gait that is discernible from humans.

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The influence of music on lexical decision-making in adolescents

Fisher et al. | Apr 28, 2024

The influence of music on lexical decision-making in adolescents

The lexical decision task is designed to test aspects of vocabulary retrieval from short-term and long-term memory by prompting the subject to differentiate between words and non-words. From this task, researchers can determine the effects of certain stimuli on linguistic processing. Numerous studies have investigated the effects of music on various cognitive capacities, like memory and vocabulary. In the current study, we hypothesized that participants would show greater accuracy rates on the lexical decision task when exposed to a selected piece of classical music while completing the task, as compared to completing the task in silence. We tested this hypothesis on a group of 25 participants who completed the lexical decision task once in silence and once while listening to Beethoven's “Moonlight Sonata, 1st Movement”. The results suggest a positive association between the effects of classical background music and improved accuracy. Our results indicate that listening to certain types of music may enhance linguistic processes such as reading and writing. Further research with a larger group of participants is necessary to better understand the association between music and linguistic processing abilities.

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Sri Lankan Americans’ views on U.S. racial issues are influenced by pre-migrant ethnic prejudice and identity

Gunawardena et al. | Apr 18, 2022

Sri Lankan Americans’ views on U.S. racial issues are influenced by pre-migrant ethnic prejudice and identity

In this study, the authors examined how Sri Lankan Americans (SLAs) view racial issues in the U.S. The main hypothesis is that SLAs, as a minority in the U.S., are supportive of the Black Lives Matter movement and its political goal, challenging the common notion that SLAs are anti-Black. The study found that a majority of SLAs believe the U.S. has systemic racism, favor BLM, and favor affirmative action. IT also found that Tamil SLAs have more favorable views of BLM and affirmative action than Sinhalese SLAs.

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Synthesis of a novel CCR1 antagonist for treatment of glioblastoma

Jan et al. | May 05, 2021

Synthesis of a novel CCR1 antagonist for treatment of glioblastoma

Glioblastoma is a brain cancer caused by the presence of a fast-growing, malignant tumor in the brain. As of now, this cancer is universally lethal due to lack of efficacious treatment options. C-C chemokine receptor 1 (CCR1) is a G-protein coupled receptor that controls chemotaxis, the movement of cells in response to chemical stimuli. This research aims to synthesize potential CCR1 antagonists by coupling carboxylic acids with a triazole core. We synthesized these compounds using a simple carboxylic acid coupling and confirmed the identity of the final compounds using nuclear magnetic resonance (NMR) spectroscopy.

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Cathodal Galvanotaxis: The Effect of Voltage on the distribution of Tetrahymena pyriformis

Zheng et al. | Jun 10, 2019

Cathodal Galvanotaxis: The Effect of Voltage on the distribution of <em>Tetrahymena pyriformis</em>

The surface of the unicellular eukaryote, Tetrahymena pyriformis, is covered with thousands of hair-like cilia. These cilia are very similar to cilia of the human olfactory and respiratory tracts making them model organisms for studying cilia function and pathology. The authors of this study investigated the effect of voltage on T. pyriformis galvanotaxis, the movement towards an electrical stimulus. They observed galvanotaxis towards the cathode at voltages over 4V which plateau, indicating opening of voltage gated-ion channels to trigger movement.

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Shortage of Black physicians: Florida Black medical student enrollment from 2013 to 2021

Khan et al. | Sep 18, 2024

Shortage of Black physicians: Florida Black medical student enrollment from 2013 to 2021

Black patients tend to have better health outcomes when cared for by Black physicians, yet Black doctors make up only 5% of U.S. physicians, despite Black people comprising 14% of the population. This analysis of data from Florida medical schools showed a higher enrollment of Black first-year students (13.5%) compared to the national average (9%), and a national increase from 6% in 2013 to 9% in 2021, aligning with the rise of social justice movements. Increasing Black medical student enrollment could reduce health disparities and improve outcomes for Black communities.

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