Medicinal plants could be a good source of medication to combat antibiotic resistance. Dombeya wallichii, which is commonly called Pink Ball Tree in the family Sterculiaceae, has been documented to have medicinal potential. We observed the highest antibacterial activity in the stem extracts, followed by leaf and bark extracts. The extracts were more effective against tested Gram-positive bacteria when compared with Gram-negative strains.

Major depressive disorder (MDD) is a prevalent mood disorder. The direct causes and biological mechanisms of depression still elude understanding, though genetic factors have been implicated. This study looked to identify the mechanism behind the aberrant response to the dexamethasone suppression test (DST) displayed by MDD patients, in which they display a lack of cortisol suppression. Analysis revealed several pro-inflammatory genes that were significant and differentially expressed between affected and non-affected groups in response to the DST. Looking at ways to decrease the inflammatory response could have implications for treatment and may explain why some people treated for depression still display symptoms or may lead researchers to different classes of drugs for treatment.

Complications of robotic-assisted surgery are on the rise, partly due to surgeons not receiving proper training. Al-Akash and Al-Akash hypothesized Nintendo JoyCon controls would improve surgical performance compared to the FDA-approved Da Vinci Surgical System with two user groups (doctor and gamer). Their results show that implementing a Nintendo JoyCon control system is associated with improved surgical performance and learning rate compared to the Da Vinci Surgical System.

The degeneration of nerve cells in the brain can lead to pathologies such as Parkinson’s disease. It has been suggested that neurons in humans may regenerate. In this study, the effect of different doses of caffeine on regeneration was explored in the planeria model. Caffeine has been shown to enhance dopamine production, and dopamine is found in high concentrations in regenerating planeria tissues. Higher doses of caffeine accelerated planeria regeneration following decapitation, indicating a potential role for caffeine as a treatment to stimulate regeneration.

Scientists are always on the quest to improve the body's healing abilities and broken bones are no exception. In this article, the authors investigate properties of 3D-printed biocompatible polymers used to improve bone healing. With such efforts, we can hope to, one day, improve bone scaffolding materials in ways that make the natural healing processes more efficient, reducing the time needed for recovery from bone fractures.

In a world where plastic waste accumulation is threatening both land and sea life, Green et al. investigate the ability of mealworms to breakdown polystyrene, a non-recyclable form of petrochemical-based polymer we use in our daily lives. They confirm that these organisms, can degrade various forms of polystyrene, even after it has been put to use in our daily lives. Although the efficiency of the degradation process still requires improvement, the good news is, the worms are tiny and themselves are biodegradable, so we can use plenty of them without worrying about space and how to get rid of them. This is very promising and certainly good news for the planet.

The "Uncanny Valley" is a phenomenon in which humans feel discomfort in the presence of objects that are almost, but not quite, human-like. In this study, the authors tested whether this phenomenon could be overcome by sharing a stressful experience with a humanoid robot. They found that human subjects more readily accepted a robot partner that they had previously shared a stressful experience with, suggesting a potential method for increasing the effectiveness of beneficial human-robot interactions by reducing the Uncanny Valley effect.

Numerous organisms, including the marine bacterium Aliivibrio fischeri, produce light. This bioluminescence is involved in many important symbioses and may one day be an important source of light for humans. In this study, the authors investigated ways to increase bioluminescence production from the model organism E. coli.

The authors test the antiproliferative and apoptosis-inducing properties of an extract created from a traditional Indian medicinal plant of the Amaranthus genus.

The authors explore how similar exoplanets are to Earth and whether they could be inhabited by humans and other living organisms.