In this study, the authors use high-throughput virtual screening to design and evaluate a set of non-nucleoside reverse transcriptase inhibitors for binding affinity to the protein reverse transcriptase. These studies have important applications toward HIV therapies.

Each day we are flooded with new items that promise us a better experience at a better price. This forces buyers to continuously chose between sticking to what they know, or trying something new. In turn, companies need to be aware of the factors affecting consumer choices, that too within the different fractions of society. In this study the authors investigate the effect of survey-based price setting on profits made based on African American teen purchases, and how African-American teen loyalty to a particular brand affects their willingness to pay a higher price than the market average for their preferred brand items.

With advancements in machine learning a large data scale, high throughput virtual screening has become a more attractive method for screening drug candidates. This study compared the accuracy of molecular descriptors from two cheminformatics Mordred and PaDEL, software libraries, in characterizing the chemo-structural composition of 53 compounds from the non-nucleoside reverse transcriptase inhibitors (NNRTI) class. The classification model built with the filtered set of descriptors from Mordred was superior to the model using PaDEL descriptors. This approach can accelerate the identification of hit compounds and improve the efficiency of the drug discovery pipeline.

Here the authors used morphological characters and DNA barcoding to identify arthropods found within a residential house. With this method they identified their species and compared them against pests lists provided by the US government. They found that none of their identified species were considered to be pests providing evidence against the misconception that arthropods found at home are harmful to humans. They suggest that these methods could be used at larger scales to better understand and aid in mapping ecosystems.

In this study, the authors identify new potential targets to treat advanced diffuse large B-cell lymphoma after treatment relapse and loss of CD19 expression.

Do different physical traits affect teenagers’ initial trust of an unknown person? Would they give greater trust to women and people of similar ethnicity? To test these hypotheses, the authors developed a survey to determine the sets of physical characteristics that affect a person's trustworthiness. They found that gender and expression were the main physical traits associated with how trustworthy an individual looks, while ethnicity was also important.

Inherent bias is often the unconscious driver of human behavior, and the first step towards overcoming these biases is our awareness of them. In this article the authors investigate whether race, gender or species affect the choice of charity by middle class Spaniards. Their conclusions serve as a starting point for further studies that could help charities refine their campaigns in light of these biases effectively transcending them or taking advantage of them to improve their fundraising attempts.

This article investigates the study methodologies, learning strategies, and motives of spelling bee participants. The authors identify several important educational implications of this work.

This study compares the voltage output of two potential alternative energy sources: water drops hitting a piezoelectric surface and water flowing through a hydroelectric turbine. The findings of this study suggest that harnessing kinetic energy from falling raindrops may be a viable alternative energy source.

Racial inequality has been a major issue throughout the history of the United States. In recent years, however, especially with the election of America's first black president, many have claimed that we have made progress and are moving towards a post-racial society. The authors of this study sought to test that claim by evaluating whether high school age students still experience a phenomenon known as white guilt. White guilt is defined as remorse or shame felt by people of Caucasian descent about racial inequality.