The authors investigate the ability of machine learning models to developing new drug-like molecules by learning desired chemical properties versus simply generating molecules that similar to those in the training set.
Read More...Evaluating the feasibility of SMILES-based autoencoders for drug discovery
The authors investigate the ability of machine learning models to developing new drug-like molecules by learning desired chemical properties versus simply generating molecules that similar to those in the training set.
Read More...Modeling and optimization of epidemiological control policies through reinforcement learning
Pandemics involve the high transmission of a disease that impacts global and local health and economic patterns. Epidemiological models help propose pandemic control strategies based on non-pharmaceutical interventions such as social distancing, curfews, and lockdowns, reducing the economic impact of these restrictions. In this research, we utilized an epidemiological Susceptible, Exposed, Infected, Recovered, Deceased (SEIRD) model – a compartmental model for virtually simulating a pandemic day by day.
Read More...An analysis of junior rower performance and how it is affected by rower's features
In this study, with consideration for the increasing participation of high school students in indoor rowing, the authors analyzed World Indoor Rowing Championship data. Statistical analysis revealed two key features that can determine the performance of a rower as well as increasing competitiveness in nearly all categories considered. They conclude by offering a 2000-meter ergometer time distribution that can help junior rowers assess their current performance relative to the world competition.
Read More...Expressional correlations between SERPINA6 and pancreatic ductal adenocarcinoma-linked genes
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer, with early diagnosis and treatment challenges. When any of the genes KRAS, SMAD4, TP53, and BRCA2 are heavily mutated, they correlate with PDAC progression. Cellular stress, partly regulated by the gene SERPINA6, also correlates with PDAC progression. When SERPINA6 is highly expressed, corticosteroid-binding globulin inhibits the effect of the stress hormone cortisol. In this study, the authors explored whether there is an inverse correlation between the expression of SERPINA6 and PDAC-linked genes.
Read More...String analysis of exon 10 of the CFTR gene and the use of Bioinformatics in determination of the most accurate DNA indicator for CF prediction
Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene. In this paper, the authors attempt to identify variations in stretches of up to 8 nucleotides in the protein-coding portions of the CFTR gene that are associated with disease development. This would allow screening of newborns or even fetuses in utero to determine the likelihood they develop cystic fibrosis.
Read More...Decreasing heart rate after consuming caffeine
The authors investigate various methods to decrease heart rate after drinking caffeine.
Read More...Comparing model-centric and data-centric approaches to determine the efficiency of data-centric AI
In this study, three models are used to test the hypothesis that data-centric artificial intelligence (AI) will improve the performance of machine learning.
Read More...Differentiation of Waste Plastic Pyrolysis Fuels to Conventional Diesel Fuel
Plastic pollution and energy shortages are pressing issues in today’s world. The authors examined whether waste plastic pyrolysis fuels are similar to conventional diesel and, thus, a plausible alternative fuel. Results showed that waste plastic pyrolysis fuels did not match up to diesel overall, though several fuels came close in calorific value.
Read More...Investigation of Bunsen-type Premixed Flame Response to Acoustic Excitation: Temperature and Flame Profile
Here, authors characterize how different acoustics affect the properties of a Bunsen-type flame.
Read More...Investigating Teen Audism: The Development and Use of a Survey Scale to Measure Misconceptions of the Deaf Community in a Hearing High School
The authors explore hearing students' misconceptions about the Deaf and Hard of Hearing (HoH) community. Results indicate that some misconceptions are more common than others, and that personal experience with individuals in the Deaf and HoH community reduces the frequency of such misconceptions.
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