
In this study, the authors determine which house model is most resistant to high winds by building smaller prototypes that could be tested with a handheld source of wind.
Read More...An accessible experiment to assess the impact of shapes of buildings and roofs on wind resistance
In this study, the authors determine which house model is most resistant to high winds by building smaller prototypes that could be tested with a handheld source of wind.
Read More...Thermoelectric cooling in greenhouses: Implications for small-holder production
The authors set to test a system that would help with the dehumidification and overall management of greehouses.
Read More...Linear and non-linear summation of responses to visual and olfactory cues in male Drosophila melanogaster
In this study, the authors investigate whether phototaxis and odortaxis in Drosophila melanogaster occurs through linear summation of cues including light and attractive odorants.
Read More...An optimal pacing approach for track distance events
In this study, the authors use existing mathematical models to how high school athletes pace 800 m, 1600 m, and 3200 m distance track events compared to elite athletes.
Read More...Elevated levels of IL-8, TGF-β, and TNF-α associated with pneumoconiosis: A meta-analysis
The authors looked at previous studies to evaluate the ability to use serum levels of certain cytokines as biomarkers for pneumoconiosis.
Read More...Indole-3 carbinol on lipid accumulation in Caenorhabditis elegans as a novel therapeutic for Type II Diabetes
In this study the authors look at the use of Indole 3 Carbinol as a treatment for Type II Diabetes finding that it may be an effective treatment.
Read More...Managing CO2 levels through precipitation-based capture from seawater and electrochemical conversion
The authors set out to develop an electrochemical device that would have efficient and sustained carbon dioxide capture.
Read More...Increased carmine red exposure periods yields a higher number of vacuoles formed in Tetrahymena pyriformis
T. pyriformis can use phagocytosis to create vacuoles of carmine red, a dye which is made using crushed insects and is full of nutrients. Establishing a relationship between vacuole formation and duration of exposure to food can demonstrate how phagocytosis occurs in T. pyriformis. We hypothesized that if T. pyriformis was incubated in a carmine red solution, then more vacuoles would form over time in each cell.
Read More...Computational development of aryl sulfone compounds as potential NNRTIs
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are allosteric inhibitors that bind to the HIV reverse transcriptase and prevent replication. Indolyl aryl sulfones (IAS) and IAS derivatives have been found to be highly effective against mutant strains of HIV-1 reverse transcriptase. Here, we analyzed molecules designed using aryl sulfone scaffolds paired to cyclic compounds as potential NNRTIs through the computational design and docking of 100 novel NNRTI candidates. Moreover, we explored the specific combinations of functional groups and aryl sulfones that resulted in the NNRTI candidates with the strongest binding affinity while testing all compounds for carcinogenicity. We hypothesized that the combination of an IAS scaffold and pyrimidine would produce the compounds with the best binding affinity. Our hypothesis was correct as the series of molecules with an IAS scaffold and pyrimidine exhibited the best average binding affinity. Additionally, this study found 32 molecules designed in this procedure with higher or equal binding affinities to the previously successful IAS derivative 5-bromo-3-[(3,5-dimethylphenyl)sulfonyl]indole-2-carboxyamide when docked to HIV-1 reverse transcriptase.
Read More...Exposure to Schistosoma mansoni antigen induces an allergic response to peanuts in an American cockroach model
Pillai et al. look at whether exposure to Schistosoma mansoni, a parasitic blood fluke, has any relation to peanut allergies. They found that cockroaches exposed to an antigen found in S. mansoni eggs exhibited an allergic reaction to peanuts.
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