Naturally occurring neuroactive alkaloids are often studied for their potential to treat Neurological diseases. This team of students study Rivastigmine, a potent cholinesterase inhibitor that is a synthetic analog of physostigmine, which comes from the Calabar bean plant Physostigma venenosum. By comparing the effects of optimized synthetic analogs to the naturally occurring alkaloid, they determine the most favorable analog for inhibition of acetylcholinesterase (AChE), the enzyme that breaks down the neurotransmitter acetylcholine (ACh) to terminate neuronal transmission and signaling between synapses.

Here, seeking to develop an understanding of the properties that determine the viability of piezoelectric flexible materials for applications in electro-mechanical sensors, the authors investigated the effects of the inclusion BaTiO₃ nanoparticles in electrospun Polyvinyledene Fluoride. They found the voltage generated had a piecewise linear dependence on the applied force at a few temperatures.

In order for cells to successfully multiply, a number of proteins are needed to correctly coordinate the replication and division process. In this study, students use fluorescence microscopy and molecular methods to study CCDC11, a protein critical in the formation of cilia. Interestingly, they uncover a new role for CCDC11, critical in the cell division across multiple human cell lines.

The sugar-rich modern diet underlies a suite of metabolic disorders, most common of which is diabetes. Accurately reporting the sugar content of pre-packaged food and drink items can help consumers track their sugar intake better, facilitating more cognisant and, eventually, moderate consumption of high-sugar items. In this article, the authors examine the effect of several variables on the accuracy of Fehling's reaction, a colorimetric reaction used to estimate sugar content.

Superabsorbent beads are remarkable, used throughout our daily lives for various practical applications. These beads, as suggested by their name, possess a unique ability to absorb and retain large quantities of liquids. This characteristic of absorbency makes them essential throughout the medical field, agriculture, and other critical industries as well as in everyday products. To create these beads, the process of photopolymerization is fast growing in favor with distinct advantages of cost efficiency, speed, energy efficiency, and mindfulness towards the environment. In this article, researchers explore the pairing of cheap monomers with accessible equipment for creation of superabsorbent beads via the photopolymerization process. This research substantially demonstrates the successful application of photopolymerization in producing highly absorbent beads in a low-cost context, thereby expanding the accessibility of this process for creating superabsorbent beads in both research and practical applications.

Here recognizing the importance of urban green space for the health of humans and other organisms, the authors investigated if mathematical modeling can be used to develop an urban greenery management plan with high eco-sustainability by calculating the composition of a plant community. They optimized and tested their model against green fields in a Beijing city park. Although the compositions predicted by their models differed somewhat from the composition of testing fields, they conclude that by using a mathematical model such as this urban green space can be finely designed to be ecologically and economically sustainable.

The surface of the unicellular eukaryote, Tetrahymena pyriformis, is covered with thousands of hair-like cilia. These cilia are very similar to cilia of the human olfactory and respiratory tracts making them model organisms for studying cilia function and pathology. The authors of this study investigated the effect of voltage on T. pyriformis galvanotaxis, the movement towards an electrical stimulus. They observed galvanotaxis towards the cathode at voltages over 4V which plateau, indicating opening of voltage gated-ion channels to trigger movement.

Clean drinking water is an essential component to maintaining public health. The authors of this study tested the bacterial load of water from three different disinfection and filtration systems in order to determine which system might be superior.

The authors analyzed biosolids from five Wisconsin wastewater treatment plants and suggest using KBr pellet FTIR as a simple and rapid method to start characterizing P species in biosolids.

At a crime scene, the presence and pattern of gunshot residue can help forensic scientists piece together the events that occurred. To assist this, the authors of this paper determined the relationship between shooting distance and nitrite residue patterns left on fabric targets.