Pichia kudriavzevii Yeast Exposure Increases the Asthmatic Behavior of Alveolar Epithelial Cells In Vitro
(1) American Heritage School, Plantation, Florida
https://doi.org/10.59720/18-021![Cover photo for <em>Pichia kudriavzevii</em> Yeast Exposure Increases the Asthmatic Behavior of Alveolar Epithelial Cells <em>In Vitro</em>](https://emerginginvestigators.org/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBclVCIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--55296540e9400be23eb485d6f4612085e04b7d8e/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJY0c1bkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--33b2b080106a274a4ca568f8742d366d42f20c14/asthma_before-after.png)
Asthma is a respiratory disorder that is characterized by the obstruction of the airway due to mucus overproduction and inflammation. More than 334 million people worldwide are affected by asthma. Pichia kudriavzevii is a spoilage yeast that is abundant in the environment and therefore a proficient pathogen. In this study, we observed the asthmatic effects of Pichia kudriavzevii on alveolar epithelial cells through a trypan blue assay (viability), TUNEL assay (apoptosis), PAS stain (mucin presence), and an ELISA immunoassay (IL-6 hypersecretion). Results from the assays displayed a direct correlation between infection duration and asthmatic characteristics. Thus, the Pichia kudriavzevii yeast may be a common cause of asthma-related symptoms and is a worthy cause of further study.
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