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Pichia kudriavzevii yeast exposure increases the asthmatic behavior of alveolar epithelial cells in vitro

Ortega et al. | Jun 07, 2019

Pichia kudriavzevii yeast exposure increases the asthmatic behavior of alveolar epithelial cells in vitro

Asthma affects over 334 million people worldwide and is triggered by inhalation of environmental stimuli. The authors of this study characterized the effect of exposure to common spoilage yeast, Pichia kidriavzevii, on alveolar epithelial cells. A direct correlation between infection duration and asthmatic status of these cells was found, indicating the potential for this yeast to be an environmental stimulus of asthma and warranting further study.

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Modulation of planaria regeneration by Resolvin D1 and the omega-3 fatty acid precursor 17-hydroxy docosahexaenoic acid

Chan et al. | Aug 13, 2019

Modulation of planaria regeneration by Resolvin D1 and the omega-3 fatty acid precursor 17-hydroxy docosahexaenoic acid

Omega-3 fatty acids ingested in the diet are essential for regulating many functions in the body including controlling inflammation in chronic conditions such as arthritis as asthma. Omega-3 fatty acid derived lipid mediators have been implicated in resolving inflammation, tissue homeostasis and wound healing. To further explore this effect, Chan and Chatterjee measured the impact of supplementation with lipid mediator Resolvin D1 and its precursor 17-HDHA on planaria regeneration. For the first time planaria have been shown to synthesize RvD1 from 17-DHA. Further, both RvD1 and 17-DHA enhanced regeneration showing potential for enhanced regenerative responses in tissues.

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