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Evaluation of Microplastics in Japanese Fish Using Visual and Chemical Dissections

Srebnik et al. | Jan 20, 2021

Evaluation of Microplastics in Japanese Fish Using Visual and Chemical Dissections

Does the overuse of plastic in Japan poses an ecological risk to marine species and their consumers? Using visual and chemical dissection, all fish in this study were found to have microplastics present in their gastrointestinal tract, including two species that are typically eaten whole in Japan. Overall, these results are concerning as previous studies have found that microplastics can carry persistent organic pollutants. It is presumed that the increasing consumption of microplastics will have negative implications on organ systems such as the liver, gut, and hormones.

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High-throughput virtual screening of novel dihydropyrimidine monastrol analogs reveals robust structure-activity relationship to kinesin Eg5 binding thermodynamics

Shern et al. | Jan 20, 2021

High-throughput virtual screening of novel dihydropyrimidine monastrol analogs reveals robust structure-activity relationship to kinesin Eg5 binding thermodynamics

As cancer continues to take millions of lives worldwide, the need to create effective therapeutics for the disease persists. The kinesin Eg5 assembly motor protein is a promising target for cancer therapeutics as inhibition of this protein leads to cell cycle arrest. Monastrol, a small dihydropyrimidine-based molecule capable of inhibiting the kinesin Eg5 function, has attracted the attention of medicinal chemists with its potency, affinity, and specificity to the highly targeted loop5/α2/α3 allosteric binding pocket. In this work, we employed high-throughput virtual screening (HTVS) to identify potential small molecule Eg5 inhibitors from a designed set of novel dihydropyrimidine analogs structurally similar to monastrol.

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Exploring a Possible Link Between ADHD and Inattentional Blindness

Younger et al. | Dec 21, 2020

Exploring a Possible Link Between ADHD and Inattentional Blindness

Attention Deficit Hyperactivity Disorder (ADHD) is characterized by impulsivity, hyperactivity, and inattention. The authors hypothesized that people with ADHD would display more inattentional blindness in perceptually simple tasks and less inattentional blindness in perceptually complex tasks. The results indicate that there is no significant correlation between ADHD and inattentional blindness in either type of task.

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