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In this article the authors created an interaction map of proteins involved in colorectal cancer to look for driver vs. non-driver genes. That is they wanted to see if they could determine what genes are more likely to drive the development and progression in colorectal cancer and which are present in altered states but not necessarily driving disease progression.

In 2021, over 20 million people died from cardiovascular diseases, highlighting the need for a deeper understanding of factors influencing heart failure outcomes. This study examined multiple variables affecting mortality after heart failure, using random forest models to identify time, serum creatinine, and ejection fraction as key predictors. These findings could contribute to personalized medicine, improving survival rates by tailoring treatment strategies for heart failure patients.

With advancements in machine learning a large data scale, high throughput virtual screening has become a more attractive method for screening drug candidates. This study compared the accuracy of molecular descriptors from two cheminformatics Mordred and PaDEL, software libraries, in characterizing the chemo-structural composition of 53 compounds from the non-nucleoside reverse transcriptase inhibitors (NNRTI) class. The classification model built with the filtered set of descriptors from Mordred was superior to the model using PaDEL descriptors. This approach can accelerate the identification of hit compounds and improve the efficiency of the drug discovery pipeline.

Triggered largely by the warming and pollution of oceans, corals are experiencing bleaching and a variety of diseases caused by the spread of bacteria, fungi, and viruses. Identification of bleached/diseased corals enables implementation of measures to halt or retard disease. Benthic cover analysis, a standard metric used in large databases to assess live coral cover, as a standalone measure of reef health is insufficient for identification of coral bleaching/disease. Proposed herein is a solution that couples machine learning with crowd-sourced data – images from government archives, citizen science projects, and personal images collected by tourists – to build a model capable of identifying healthy, bleached, and/or diseased coral.

The authors looked at using machine learning to identify skills needed to apply for certain jobs, specifically looking at different techniques to parse apart the text. They found that Bidirectional Encoder Representation of Transforms (BERT) performed best.

The authors train a neural network to detect text-based emotions including joy, sadness, anger, fear, love, and surprise.

Pediatric cancers pose unique challenges due to their rarity and distinct biological factors, emphasizing the need for accurate survival prediction to guide treatment. This study integrated generative AI and machine learning, including synthetic data, to analyze 9,184 pediatric cancer patients, identifying age at diagnosis, cancer types, and anatomical sites as significant survival predictors. The findings highlight the potential of AI-driven approaches to improve survival prediction and inform personalized treatment strategies, with broader implications for innovative healthcare applications.

Sequence accessibility is an important factor affecting gene expression. Sequence accessibility or openness impacts the likelihood that a gene is transcribed and translated into a protein and performs functions and manifests traits. There are many potential factors that affect the accessibility of a gene. In this study, our hypothesis was that the content of nucleotides in a genetic sequence predicts its accessibility. Using a machine learning linear regression model, we studied the relationship between nucleotide content and accessibility.

In this article the authors looked at different attributes of apps within the Google Play store to determine how those may impact the overall app rating out of five stars. They found that review count, amount of storage needed and when the app was last updated to be the most influential factors on an app's rating.

Auto-Regressive Integrated Moving Average (ARIMA) models are known for their influence and application on time series data. This statistical analysis model uses time series data to depict future trends or values: a key contributor to crime mapping algorithms. However, the models may not function to their true potential when analyzing data with many different patterns. In order to determine the potential of ARIMA models, our research will test the model on irregularities in the data. Our team hypothesizes that the ARIMA model will be able to adapt to the different irregularities in the data that do not correspond to a certain trend or pattern. Using crime theft data and an ARIMA model, we determined the results of the ARIMA model’s forecast and how the accuracy differed on different days with irregularities in crime.