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Analyzing relationships and distribution between age, sex, and eye disease at IGMCH eye OPD

Sareen et al. | Feb 20, 2025

Analyzing relationships and distribution between age, sex, and eye disease at IGMCH eye OPD
Image credit: Amanda Dalbjörn

This study analyzed patient demographics in the ophthalmology department at Indira Gandhi Medical College and Hospital (IGMCH) to assess relationships between age, sex, and eye conditions. While the overall sex distribution was equal, individual conditions varied, with cataracts and retinal disorders more common in males and conjunctival conditions slightly more prevalent in females, though none were statistically significant (p > 0.05) except for cataract patients aged 50–89 (p < 0.001). Understanding these trends can help medical facilities allocate resources more effectively for improved patient care.

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Singlet oxygen production analysis of reduced berberine analogs via NMR spectroscopy

Su et al. | Feb 10, 2023

Singlet oxygen production analysis of reduced berberine analogs via NMR spectroscopy

Berberine is a natural product isoquinoline alkaloid derived from plants of the genus Berberis. When exposed to photoirradiation, it produces singlet oxygen through photosensitization of triplet oxygen. Through qNMR analysis of 1H NMR spectra gathered through kinetic experiments, we were able to track the generation of a product between singlet oxygen and alpha terpinene, allowing us to quantitatively measure the photosensitizing properties of our scaffolds.

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Synthesis of sodium alginate composite bioplastic films

Kim et al. | Sep 17, 2024

Synthesis of sodium alginate composite bioplastic films

The authors looked at the development of biodegradable bioplastic and its features compared to PET packaging films. They were able to develop a biodegradable plastic with sodium alginate that dissolved in water and degrade in microbial conditions while also being transparent and flexible similar to current plastic films.

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How are genetically modified foods discussed on TikTok? An analysis of #GMOFOODS

Basch et al. | Nov 20, 2023

How are genetically modified foods discussed on TikTok? An analysis of #GMOFOODS
Image credit: Camilo Jimenez

Here, the authors investigated engagement with #GMOFOODS, a hashtag on TikTok. They hypothesized that content focused on the negative effects of genetically modified organisms would receive more interaction driven by consumers. They found that the most common cateogry focused on the disadvantages of GMOs related to nutrition and health with the number of views determining if the video would be provided to users.

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Modular mimics of neuroactive alkaloids - design, synthesis, and cholinesterase inhibitory activity of rivastigmine analogs

Yu et al. | Sep 12, 2022

Modular mimics of neuroactive alkaloids - design, synthesis, and cholinesterase inhibitory activity of rivastigmine analogs

Naturally occurring neuroactive alkaloids are often studied for their potential to treat Neurological diseases. This team of students study Rivastigmine, a potent cholinesterase inhibitor that is a synthetic analog of physostigmine, which comes from the Calabar bean plant Physostigma venenosum. By comparing the effects of optimized synthetic analogs to the naturally occurring alkaloid, they determine the most favorable analog for inhibition of acetylcholinesterase (AChE), the enzyme that breaks down the neurotransmitter acetylcholine (ACh) to terminate neuronal transmission and signaling between synapses.

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Computational Structure-Activity Relationship (SAR) of Berberine Analogs in Double-Stranded and G-Quadruplex DNA Binding Reveals Both Position and Target Dependence

Sun et al. | Dec 18, 2020

Computational Structure-Activity Relationship (SAR) of Berberine Analogs in Double-Stranded and G-Quadruplex DNA Binding Reveals Both Position and Target Dependence

Berberine, a natural product alkaloid, and its analogs have a wide range of medicinal properties, including antibacterial and anticancer effects. Here, the authors explored a library of alkyl or aryl berberine analogs to probe binding to double-stranded and G-quadruplex DNA. They determined that the nature of the substituent, the position of the substituent, and the nucleic acid target affect the free energy of binding of berberine analogs to DNA and G-quadruplex DNA, however berberine analogs did not result in net stabilization of G-quadruplex DNA.

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Discovery of the Heart in Mathematics: Modeling the Chaotic Behaviors of Quantized Periods in the Mandelbrot Set

Golla et al. | Dec 14, 2020

Discovery of the Heart in Mathematics: Modeling the Chaotic Behaviors of Quantized Periods in the Mandelbrot Set

This study aimed to predict and explain chaotic behavior in the Mandelbrot Set, one of the world’s most popular models of fractals and exhibitors of Chaos Theory. The authors hypothesized that repeatedly iterating the Mandelbrot Set’s characteristic function would give rise to a more intricate layout of the fractal and elliptical models that predict and highlight “hotspots” of chaos through their overlaps. The positive and negative results from this study may provide a new perspective on fractals and their chaotic nature, helping to solve problems involving chaotic phenomena.

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