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Validating DTAPs with large language models: A novel approach to drug repurposing

Curtis et al. | Mar 02, 2025

Validating DTAPs with large language models: A novel approach to drug repurposing
Image credit: Growtika

Here, the authors investigated the integration of large language models (LLMs) with drug target affinity predictors (DTAPs) to improve drug repurposing, demonstrating a significant increase in prediction accuracy, particularly with GPT-4, for psychotropic drugs and the sigma-1 receptor. This novel approach offers to potentially accelerate and reduce the cost of drug discovery by efficiently identifying new therapeutic uses for existing drugs.

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The correlation between bacteria and colorectal cancer

Zhang et al. | Oct 21, 2024

The correlation between bacteria and colorectal cancer

The authors looked at abundance of bacteria in stool samples from patients with colorectal cancer compared to controls. They found different bacteria that was more prevalent in patients with colorectal cancer as well as bacteria in control patients that may indicate a beneficial gut microbiome.

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Digestion products of bread and cheese cause addictive behavior in a planaria model

Cochin et al. | Sep 26, 2024

Digestion products of bread and cheese cause addictive behavior in a planaria model

The authors looked at two peptides, gluteomorphin and casomorphin, that are present after the digestion of bread and cheese. As these peptides can bind opioid receptors the authors want to know if they could be addictive in the same way as conventional opioids (i.e., morphine) are known to be. Their results in a planaria model suggest that both of these peptides are addictive.

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