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The effect of joint angle differences on blade velocity in elite and novice saber fencers: A kinematic study

Greene et al. | Mar 02, 2023

 The effect of joint angle differences on blade velocity in elite and novice saber fencers: A kinematic study

Here, recognizing that years of training in saber fencing could expectedly result in optimized movements that result in elite skill levels, the authors used motion tracking and statistical analysis to assess the difference in velocity and blade tip velocity of novice and elite fencers during a vertical blade thrust. They found statistically significant differences in blade tip velocity and elbow joint angle kinematics.

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Applying centrality analysis on a protein interaction network to predict colorectal cancer driver genes

Saha et al. | Nov 18, 2023

Applying centrality analysis on a protein interaction network to predict colorectal cancer driver genes

In this article the authors created an interaction map of proteins involved in colorectal cancer to look for driver vs. non-driver genes. That is they wanted to see if they could determine what genes are more likely to drive the development and progression in colorectal cancer and which are present in altered states but not necessarily driving disease progression.

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Model selection and optimization for poverty prediction on household data from Cambodia

Wong et al. | Sep 29, 2023

Model selection and optimization for poverty prediction on household data from Cambodia
Image credit: Paul Szewczyk

Here the authors sought to use three machine learning models to predict poverty levels in Cambodia based on available household data. They found teat multilayer perceptron outperformed the other models, with an accuracy of 87 %. They suggest that data-driven approaches such as these could be used more effectively target and alleviate poverty.

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Starts and Stops of Rhythmic and Discrete Movements: Modulation in the Excitability of the Corticomotor Tract During Transition to a Different Type of Movement

Lim et al. | Aug 27, 2018

Starts and Stops of Rhythmic and Discrete Movements: Modulation in the Excitability of the Corticomotor Tract During Transition to a Different Type of Movement

Control of voluntary and involuntary movements is one of the most important aspects of human neurological function, but the mechanisms of motor control are not completely understood. In this study, the authors use transcranial magnetic stimulation (TMS) to stimulate a portion of the motor cortex while subjects performed either discrete (e.g. throwing) or rhythmic (e.g. walking) movements. By recording electrical activity in the muscles during this process, the authors showed that motor evoked potentials (MEPs) measured in the muscles during TMS stimulation are larger in amplitude for discrete movements than for rhythmic movements. Interestingly, they also found that MEPs during transitions between rhythmic and discrete movements were nearly identical and larger in amplitude than those recorded during either rhythmic or discrete movements. This research provides important insights into the mechanisms of neurological control of movement and will serve as the foundation for future studies to learn more about temporal variability in neural activity during different movement types.

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Toxicity of aminomethylphosphonic acid via the Wnt signaling pathway as a novel mechanism

Zhuang et al. | Mar 08, 2023

Toxicity of aminomethylphosphonic acid via the Wnt signaling pathway as a novel mechanism
Image credit: Image credit: Dapur Melodi

The Wnt signaling pathway, known to coordinate important aspects of cellular homeostasis ranging from differentiation, proliferation, migration, and much more, is dysregulated in many human diseases. This study demonstrates that aminomethylphosphonic acid, which is the main metabolite found in the common herbicide Glyphosate, is toxic to planaria and capable of binding to canonical Wnt proteins.

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Effects of Prolonged Azithromycin Therapy on Bacterial Resistance to Functionally Analogous Antibiotics

Gibbs et al. | Dec 04, 2020

Effects of Prolonged Azithromycin Therapy on Bacterial Resistance to Functionally Analogous Antibiotics

In this study, the authors investigate a potential case of cross antibiotic-resistance. Using swabs from an individual who received long-term treatments of azithromycin, they addressed the question of whether any bacteria in this individual might develop resistance to not only azithromycin, but also other antibiotics with similar structures. This study cleverly addresses the important issue of antibiotic resistance from a new and thoughtful approach.

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Comparative Analysis of Vital Capacities of Athletes, Singers and Other Students of Age 13-14 Years: A Cross-Sectional Observational Study

Taneja et al. | Sep 30, 2019

Comparative Analysis of Vital Capacities of Athletes, Singers and Other Students of Age 13-14 Years: A Cross-Sectional Observational Study

Physical activity when performed regularly has beneficial effects on all systems of the body, including pulmonary functions. This study, conducted at Springdales School in Dhaula Kuan, New Delhi, aimed to determine the effect of sports and singing on the vital capacity (the maximum amount of air a person can expel from the lungs after a maximum inhalation), an important measure of pulmonary health.

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