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The effect of caffeine on the regeneration of Brown Planaria (Dugesia tigrina)

Lazorik et al. | May 10, 2019

The effect of caffeine on the regeneration of Brown Planaria (Dugesia tigrina)

The degeneration of nerve cells in the brain can lead to pathologies such as Parkinson’s disease. It has been suggested that neurons in humans may regenerate. In this study, the effect of different doses of caffeine on regeneration was explored in the planeria model. Caffeine has been shown to enhance dopamine production, and dopamine is found in high concentrations in regenerating planeria tissues. Higher doses of caffeine accelerated planeria regeneration following decapitation, indicating a potential role for caffeine as a treatment to stimulate regeneration.

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Modulation of planaria regeneration by Resolvin D1 and the omega-3 fatty acid precursor 17-hydroxy docosahexaenoic acid

Chan et al. | Aug 13, 2019

Modulation of planaria regeneration by Resolvin D1 and the omega-3 fatty acid precursor 17-hydroxy docosahexaenoic acid

Omega-3 fatty acids ingested in the diet are essential for regulating many functions in the body including controlling inflammation in chronic conditions such as arthritis as asthma. Omega-3 fatty acid derived lipid mediators have been implicated in resolving inflammation, tissue homeostasis and wound healing. To further explore this effect, Chan and Chatterjee measured the impact of supplementation with lipid mediator Resolvin D1 and its precursor 17-HDHA on planaria regeneration. For the first time planaria have been shown to synthesize RvD1 from 17-DHA. Further, both RvD1 and 17-DHA enhanced regeneration showing potential for enhanced regenerative responses in tissues.

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3D Printed Polymer Scaffolds for Bone Tissue Regeneration

Jayatissa et al. | Apr 26, 2019

3D Printed Polymer Scaffolds for Bone Tissue Regeneration

Scientists are always on the quest to improve the body's healing abilities and broken bones are no exception. In this article, the authors investigate properties of 3D-printed biocompatible polymers used to improve bone healing. With such efforts, we can hope to, one day, improve bone scaffolding materials in ways that make the natural healing processes more efficient, reducing the time needed for recovery from bone fractures.

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Determining the Effects of Fibroblast Growth Factor 2 on the Regenerative Abilities of Echinometra lucunter Sea Urchins

Kisling et al. | Feb 12, 2019

Determining the Effects of Fibroblast Growth Factor 2 on the Regenerative Abilities of Echinometra lucunter Sea Urchins

As humans, not all our body organs can adequately regenerate after injury, an ability that declines with age. In some species, however, regeneration is a hallmark response that can occur limitless numbers of time throughout the life of an organism. Understanding how such species can regenerate so efficiently is of central importance to regenerative medicine. Sea urchins, unlike humans, can regenerate their spinal tissue after injury. Here the authors study the effect of a growth factor, FGF2, on sea urchin regeneration but find no conclusive evidence for a pro-regenerative effect after spinal tissue injury.

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The Cilium- and Centrosome-Associated Protein CCDC11 Is Required for Cytokinesis via Midbody Recruitment of the ESCRT- III Membrane Scission Complex Subunit CHMP2A

Ahmed et al. | Mar 14, 2018

The Cilium- and Centrosome-Associated Protein CCDC11 Is Required for Cytokinesis via Midbody Recruitment of the ESCRT- III Membrane Scission Complex Subunit CHMP2A

In order for cells to successfully multiply, a number of proteins are needed to correctly coordinate the replication and division process. In this study, students use fluorescence microscopy and molecular methods to study CCDC11, a protein critical in the formation of cilia. Interestingly, they uncover a new role for CCDC11, critical in the cell division across multiple human cell lines.

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