This study investigated whether chlorogenic acid, a plant compound with known health benefits, can interact with the proteins CHIT1 and CHI3L1, which could ultimately lead to new therapeutic strategies for a range of chronic diseases.
Read More...Computational prediction of chlorogenic acid binding to disease-linked proteins CHIT1 and CHI3L1
This study investigated whether chlorogenic acid, a plant compound with known health benefits, can interact with the proteins CHIT1 and CHI3L1, which could ultimately lead to new therapeutic strategies for a range of chronic diseases.
Read More...The design of Benzimidazole derivatives to bind to GDP-bound K-RAS for targeted cancer therapy
In this study, the authors looked at a proto-oncogene, KRAS, and searched for molecules that are predicted to be able to bind to the inactive form of KRAS. They found that a modified version of Irbesartan, a derivative of benzimidazole, showed the best binding to inactive KRAS.
Read More...Effect of Natural Compounds Curcumin and Nicotinamide on α-synuclein Accumulation in a C. elegans Model of Parkinson’s Disease
Parkinson's disease is a neurodegenerative disorder that affects over 10 million people worldwide. It is caused by destruction of dopamine-producing neurons, which results in severe motor and movement symptoms. In this study, the authors investigated the anti-Parkinsonian effects of two natural compounds curcumin and nicotinamide using C. elegans as a model organism.
Read More...TGFβ1 Codon 10 Polymorphism and its Association with the Prevalence of Low Myopia
The goal of this project was to assess the relationships among low myopia, behavioral and demographic factors, and a single-nucleotide polymorphism (SNP) in the TGFβ1 gene.
Read More...Strain selective in vitro and in silico structure activity relationship of tetracycline antibiotics
The authors looked at four members of the tetracycline antibiotic family/class against four different species of bacteria.
Read More...Designing gRNAs to reduce the expression of the DMPK gene in patients with classic myotonic dystrophy
The authors describe the design and testing of new guide RNAs targeting the DMPK gene, which is responsible for myotonic dystrophy.
Read More...Investigating the potential of zinc oxide nanoparticles and zinc ions as promising approaches to lung cancer
Here, the authors chose to investigate the efficacy of zinc oxide nanoparticles (ZnO NPs) and cisplatin or zinc ions in inducing cancer apoptosis. While both treatments were found to reduce the proliferation of lung cancer cells, the authors suggest that further studies to identify the mechanism are necessary.
Read More...Are Asian foods healthier than Western foods: Evidence collected from St. Louis area grocery stores
The authors compare nutritional content of foods found in Western versus Asian grocery stores to determine whether one cultural diet is healthier than the other.
Read More...Sex differences in linear polyubiquitination in the entorhinal cortex during fear memory formation
The authors explore sex-specific differences in the formation of fear memories across several rat brain regions.
Read More...Solving a new NP-Complete problem that resembles image pattern recognition using deep learning
In this study, the authors tested the ability and accuracy of a neural net to identify patterns in complex number matrices.
Read More...