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Health services in Iraq - A cross-sectional survey of adolescents in Basra

Al Saeedi et al. | Aug 12, 2022

Health services in Iraq - A cross-sectional survey of adolescents in Basra

This study is a cross-sectional survey of adolescents in Basra, Iraq, from November 2020 to March 2021 about types of adolescent problems, the individuals and institutions adolescents turn to, and the role of public health centers in dealing with their problems. The survey found that psychological problems represent the largest proportion of health problems, and most adolescents turn to their parents to discuss their problems. The work indicates that there is an urgent need to pay attention to public health centers and provide health and psychological support to adolescents.

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Mutation of the Catalytic Cysteine in Anopheles gambiae Transglutaminase 3 (AgTG3) Abolishes Plugin Crosslinking Activity without Disrupting Protein Folding Properties

Pham et al. | May 02, 2014

Mutation of the Catalytic Cysteine in <em>Anopheles gambiae</em> Transglutaminase 3 (AgTG3) Abolishes Plugin Crosslinking Activity without Disrupting Protein Folding Properties

Malaria is a major public health issue, especially in developing countries, and vector control is a major facet of malaria eradication efforts. Recently, sterile insect technique (SIT), or the release of sterile mosquitoes into the wild, has shown significant promise as a method of keeping vector populations under control. In this study, the authors investigate the Anopheles gambiae transglutaminase 3 protein (AgT3), which is essential to the mating of the Anopheles mosquito. They show that an active site mutation is able to abolish the activity of the AgT3 enzyme and propose it as a potential target for chemosterilant inhibitors.

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Investigation of the correlation between trihalomethane concentrations and socioeconomic factors in NY State

Lee et al. | Aug 19, 2023

Investigation of the correlation between trihalomethane concentrations and socioeconomic factors in NY State

Trihalomethanes, probable human carcinogens, are commonly found disinfection by-products (DBPs) in public water systems (PWS). The authors investigated the correlation between trihalomethane concentrations and socioeconomic factors in New York State, finding a negative correlation between median household income and trihalomethane concentrations. The inverse association between trihalomethanes and household income may indicate socioeconomic disparity regarding drinking water quality and the need for improved efforts to assist small- and medium-sized community water systems to lower DBP levels in New York State.

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Rhizosphere metagenome analysis and wet-lab approach to derive optimal strategy for lead remediation in situ

Bhat et al. | Jul 18, 2023

Rhizosphere metagenome analysis and wet-lab approach to derive optimal strategy for lead remediation <i>in situ</i>
Image credit: Karolina Grabowska

The Environmental Protection Agency (EPA) reports a significant number of heavy metal-contaminated sites across the United States. To address this public health concern, rhizoremediation using microbes has emerged as a promising solution. Here, a combination of soil microbes were inoculated in the rhizosphere in soil contaminated with 500 parts per million (ppm) of lead. Results showed rhizoremediation is an effective bioremediation strategy and may increase crop productivity by converting nonarable lands into arable lands.

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Trust in the use of artificial intelligence technology for treatment planning

Srivastava et al. | Sep 18, 2024

Trust in the use of artificial intelligence technology for treatment planning

As AI becomes more integrated into healthcare, public trust in AI-developed treatment plans remains a concern, especially for emotionally charged health decisions. In a study of 81 community college students, AI-created treatment plans received lower trust ratings compared to physician-developed plans, supporting the hypothesis. The study found no significant differences in AI trust levels across demographic factors, suggesting overall skepticism toward AI-driven healthcare.

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Racial disparities in school discipline in Collier County, Florida

Khan et al. | Jun 21, 2024

Racial disparities in school discipline in Collier County, Florida
Image credit: Ivan Aleksic

Here, the authorized analyzed data from the Florida Department of Education Office of Safe Schools regarding disciplinary outcomes in Collier County public schools. They reported that Black Students were more likely to receive both in-school and out-of-school suspensions than White students, which they concluded suggests racial inequities in school discipline that requires addressing as a society.

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Contrasting role of ASCC3 and ALKBH3 in determining genomic alterations in Glioblastoma Multiforme

Sriram et al. | Sep 27, 2022

Contrasting role of <i>ASCC3</i> and <i>ALKBH3</i> in determining genomic alterations in Glioblastoma Multiforme

Glioblastoma Multiforme (GBM) is the most malignant brain tumor with the highest fraction of genome alterations (FGA), manifesting poor disease-free status (DFS) and overall survival (OS). We explored The Cancer Genome Atlas (TCGA) and cBioportal public dataset- Firehose legacy GBM to study DNA repair genes Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) and Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3 (ALKBH3). To test our hypothesis that these genes have correlations with FGA and can better determine prognosis and survival, we sorted the dataset to arrive at 254 patients. Analyzing using RStudio, both ASCC3 and ALKBH3 demonstrated hypomethylation in 82.3% and 61.8% of patients, respectively. Interestingly, low mRNA expression was observed in both these genes. We further conducted correlation tests between both methylation and mRNA expression of these genes with FGA. ASCC3 was found to be negatively correlated, while ALKBH3 was found to be positively correlated, potentially indicating contrasting dysregulation of these two genes. Prognostic analysis showed the following: ASCC3 hypomethylation is significant with DFS and high ASCC3 mRNA expression to be significant with OS, demonstrating ASCC3’s potential as disease prediction marker.

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A Crossover Study Comparing the Effect of a Processed vs. Unprocessed Diet on the Spatial Learning Ability of Zebrafish

Banga et al. | Sep 18, 2022

A Crossover Study Comparing the Effect of a Processed vs. Unprocessed Diet on the Spatial Learning Ability of Zebrafish

The authors compared the short-term effects of processed versus unprocessed food on spatial learning and survival in zebrafish, given the large public concern regarding processed foods. By randomly assigning zebrafish to a diet of brine shrimp flakes (processed) or live brine shrimp (unprocessed), the authors show while there is no immediate effect on a fish's decision process between the two diets, there are significant correlations between improved learning and stress response with the unprocessed diet.

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