Naturally occurring neuroactive alkaloids are often studied for their potential to treat Neurological diseases. This team of students study Rivastigmine, a potent cholinesterase inhibitor that is a synthetic analog of physostigmine, which comes from the Calabar bean plant Physostigma venenosum. By comparing the effects of optimized synthetic analogs to the naturally occurring alkaloid, they determine the most favorable analog for inhibition of acetylcholinesterase (AChE), the enzyme that breaks down the neurotransmitter acetylcholine (ACh) to terminate neuronal transmission and signaling between synapses.
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LawCrypt: Secret Sharing for Attorney-Client Data in a Multi-Provider Cloud Architecture
In this study, the authors develop an architecture to implement in a cloud-based database used by law firms to ensure confidentiality, availability, and integrity of attorney documents while maintaining greater efficiency than traditional encryption algorithms. They assessed whether the architecture satisfies necessary criteria and tested the overall file sizes the architecture could process. The authors found that their system was able to handle larger file sizes and fit engineering criteria. This study presents a valuable new tool that can be used to ensure law firms have adequate security as they shift to using cloud-based storage systems for their files.
Read More...SOS-PVCase: A machine learning optimized lignin peroxidase with polyvinyl chloride (PVC) degrading properties
The authors looked at the primary structure of lignin peroxidase in an attempt to identify mutations that would improve both the stability and solubility of the peroxidase protein. The goal is to engineer peroxidase enzymes that are stable to help break down polymers, such as PVC, into monomers that can be reused instead of going to landfills.
Read More...Post-Traumatic Stress Disorder (PTSD) biomarker identification using a deep learning model
In this study, a deep learning model is used to classify post-traumatic stress disorder patients through novel markers to assist in finding candidate biomarkers for the disorder.
Read More...Exploring the effects of diverse historical stock price data on the accuracy of stock price prediction models
Algorithmic trading has been increasingly used by Americans. In this work, we tested whether including the opening, closing, and highest prices in three supervised learning models affected their performance. Indeed, we found that including all three prices decreased the error of the prediction significantly.
Read More...A novel calibration algorithm and its effects on heading measurement accuracy of a low-cost magnetometer
Digital compasses are essential in technology that we use in our everyday lives: phones, vehicles, and more. Li and Liu address the accuracy of these devices by presenting a new algorithm for accurately calibrating low-cost magnetometers.
Read More...An optimal pacing approach for track distance events
In this study, the authors use existing mathematical models to how high school athletes pace 800 m, 1600 m, and 3200 m distance track events compared to elite athletes.
Read More...Rubik’s cube: What separates the fastest solvers from the rest?
In this study, the authors assess the factors that allow some speedcubers to solve Rubik's Cubes faster than others.
Read More...Comparing model-centric and data-centric approaches to determine the efficiency of data-centric AI
In this study, three models are used to test the hypothesis that data-centric artificial intelligence (AI) will improve the performance of machine learning.
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