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Cancer is often caused by improper function of a few proteins, and sometimes it takes only a few proteins to malfunction to cause drastic changes in cells. Here the authors look at the genes that were mutated in patients with a type of pancreatic cancer to identify proteins that are important in causing cancer. They also determined which proteins currently lack effective treatment, and suggest that certain proteins (named KRAS, CDKN2A, and RBBP8) are the most important candidates for developing drugs to treat pancreatic cancer.

The authors looked at beach nourishment (a way to combat erosion on coasts) and resulting grain size distribution. Their work is important to understand the dynamics of erosion and it's relation to wave action and the implications this has for efforts to mitigate coastal erosion.

Additive manufacturing (AM) is transforming the production of complex metal parts, but challenges like internal cracking can arise, particularly in critical sectors such as aerospace and automotive. Traditional methods to assess cracking susceptibility are costly and time-consuming, prompting the use of machine learning (ML) for more efficient predictions. This study developed a multi-model ML pipeline that predicts solidification cracking susceptibility (SCS) more accurately by considering secondary alloy properties alongside composition, with Random Forest models showing the best performance, highlighting a promising direction for future research into SCS quantification.

The authors looked at how pharmacokinetics changed depending on the use of an in vitro or an in vivo model.

Analysis of the Sloan green and red photometry of the Type Ia supernova 2024neh

Crohn’s disease is a chronic inflammatory bowel condition with symptoms like abdominal pain, fatigue, diarrhea, and malnutrition. Though there's no cure, various treatments help manage it. This study explored the potential impact of Massa Medicata Fermentata (MMF), a fermented Chinese herbal medicine containing Saccharomyces cerevisiae, on Crohn’s disease.

The authors looked at the ability of different machine learning algorithms to predict the level of financial corruption in different countries.

The authors looked at the impact of calcium on iron absorption in mealworms, hypothesizing that calcium would inhibit iron absorption.

Due to a critical shortage of donor hearts, researchers are exploring cardiac xenotransplantation—transplanting animal hearts into humans—as a potential solution. This study synthesized nearly two decades of preclinical research to evaluate multiple factors affecting xenograft survival.

This study investigates the effects of the PROTAC compound A1874 on CT26 colon carcinoma cells, focusing on its ability to degrade the protein BRD4 and reduce cell viability. While A1874 had previously shown effectiveness in other colon cancer cell lines, its impact on CT26 cells was unknown.