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A new therapy against MDR bacteria by in silico virtual screening of Pseudomonas aeruginosa LpxC inhibitors

Liu et al. | Apr 27, 2022

A new therapy against MDR bacteria by <em>in silico</em> virtual screening of <em>Pseudomonas aeruginosa</em> LpxC inhibitors

Here, seeking to address the growing threat of multidrug-resistant bacteria (MDR). the authors used in silico virtual screening to target MDR Pseudomonas aeruginosa. They considered a key protein in its biosynthesis and virtually screened 20,000 candidates and 30 derivatives of brequinar. In the end, they identified a possible candidate with the highest degree of potential to inhibit the pathogen's lipid A synthesis.

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Examination of the underlying chemical physics of the Mpemba effect in water and other liquids

Khan et al. | Apr 20, 2023

Examination of the underlying chemical physics of the Mpemba effect in water and other liquids
Image credit: D koi

Counterintuitive in nature, the Mpemba effect asserts that hot liquid freezes faster than cold liquid. While noted throughout history by scientific minds like Aristotle, the phenomenon remains in contention with varying hypotheses for the effect proposed alongside the effect’s rise in popularity. Contributing to the research efforts surrounding the Mpemba effect, the authors in this article explore the effect in different liquids ranging in physical properties and intermolecular forces to determine potential parameters attributable to producing the Mpemba effect.

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Formation and sticking of air bubbles in water in d-block containers

Gupta et al. | Jun 21, 2021

Formation and sticking of air bubbles in water in d-block containers

Bubbles! In this study, the authors investigate the effects that different materials, temperature, and distance have on the formation of water bubbles on the surface of copper and steel. They calculated mathematical relations based on the outcomes to better understand whether interstitial hydrogen present in the d-block metals form hydrogen bonds with the water bubbles to account for the structural and mechanical stability.

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Estimation of Reproduction Number of Influenza in Greece using SIR Model

Skarpeti et al. | Nov 18, 2020

Estimation of Reproduction Number of Influenza in Greece using SIR Model

In this study, we developed an algorithm to estimate the contact rate and the average infectious period of influenza using a Susceptible, Infected, and Recovered (SIR) epidemic model. The parameters in this model were estimated using data on infected Greek individuals collected from the National Public Health Organization. Our model labeled influenza as an epidemic with a basic reproduction value greater than one.

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Blockchain databases: Encrypted for efficient and secure NoSQL key-store

Mehrota et al. | Mar 18, 2023

Blockchain databases: Encrypted for efficient and secure NoSQL key-store
Image credit: Ayushi Mehrota & David Kim

Although commonly associated with cryptocurrency, blockchains offer security that other databases could benefit from. These student authors tested a blockchain database framework, and by tracking runtime of four independent variables, they prove this framework is feasible for application.

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The role minor and major snowfall events play in New Jersey snowfall over the past 126 years

Sharma et al. | Aug 11, 2022

The role minor and major snowfall events play in New Jersey snowfall over the past 126 years

Climate records indicate that there has been a trend of decreasing annual snowfall totals throughout the United States during the peak winter season. However, New Jersey has seen a significant increase in snowfall over the past 126 years of recorded observations. The authors hypothesize that although annual snowfall has remained the same on average, the frequencies of major and minor snowfall events have noticeably increased. They found that there was no significant evidence for an increase in the frequency of minor events (1.1-inch to 4.0-inch events), but there was evidence for an increase in the frequency of major events (4.1+ inch events). The results imply that a warming climate might be opening up opportunities for more snowfall.

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Analysis of electrodialysis as a method of producing potable water

Shen et al. | May 03, 2024

Analysis of electrodialysis as a method of producing potable water

Here, seeking a way to convert the vast quantity of seawater to drinking water, the authors investigated the purification of seawater to drinking water through electrodialysis. Using total dissolved solids (TDS) as their measure, they found that electrodialysis was able to produce deionized water with TDS values under the acceptable range for consumable water.

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The most efficient position of magnets

Shin et al. | Mar 28, 2024

The most efficient position of magnets
Image credit: immo RENOVATION

Here, the authors investigated the most efficient way to position magnets to hold the most pieces of paper on the surface of a refrigerator. They used a regression model along with an artificial neural network to identify the most efficient positions of four magnets to be at the vertices of a rectangle.

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