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In this article, the authors look into what is already known about the factor affecting longevity and determine the importance of behavioral factors including alcohol consumption, smoking, and obesity on longevity. The authors quantify data from over 150 countries and, interestingly, find that the impact each factor has on longevity is at least in part dependent on the country's economic development status. Overall, they conclude that an average person’s life expectancy can increase by more than 3 years if smoking and alcohol consumption is reduced by a half and weight is decreased by 10%.

In South Asian countries, the major cause of oral cancer is reported to be chewing paan, which is comprised of betel leaf daubed with slaked lime paste and areca nut. To investigate how paan may contribute to the onset of cancer, the authors treated two immortalized cell lines with extracts of betel leaf, areca nut, and lime and evaluated how these treatments affected cell proliferation and cell death. Initial results indicate that while betel leaf alone may inhibit cell growth, areca nut promoted cancer cell survival and proliferation, even when co-treated with betel leaf. These data suggest that areca nut could exacerbate the progression of oral cancer in humans.

Major Depressive Disorder (MDD), and Post-Traumatic Stress Disorder (PTSD) are two of the fastest growing comorbid diseases in the world. Using publicly available datasets from the National Institute for Biotechnology Information (NCBI), Ravi and Lee conducted a differential gene expression analysis using 184 blood samples from either control individuals or individuals with comorbid MDD and PTSD. As a result, the authors identified 253 highly differentially-expressed genes, with enrichment for proteins in the gene ontology group 'Ribosomal Pathway'. These genes may be used as blood-based biomarkers for susceptibility to MDD or PTSD, and to tailor treatments within a personalized medicine regime.

Cardiac autonomic and structural changes may occur in temporal lobe epilepsy patients and contribute to the risk of sudden unexpected death in epilepsy patients. Choi and colleagues reviewed clinical charts to obtain patients’ lifetime seizure count, antiepileptic drug use, and history of heart disease, followed by transthoracic echocardiogram to calculate left ventricle dimensions, ejection fraction, and left ventricle mass. By comparing epilepsy patients to control subjects, they found that epilepsy patients had thinner left ventricle walls and smaller ejection fraction, but with no significant difference in left ventricle mass.

In recent years, usage of interactive electronic devices such as computers, smartphones, and tablets has increased dramatically. Many studies have examined the potential adverse effects of excessive usage of such devices on children and adolescents, but the effects on adults are not well understood. In this study, the authors examined the relationship between adult usage of interactive electronic devices and a variety of clinical measures of psychological well-being. They found that according to some metrics, higher usage of interactive electronic devices is associated with several adverse psychological outcomes, suggesting a need for more careful consideration of such usage patterns in clinical settings.

A significant percentage of cancer survivors develop a second primary cancer. Using data of deceased patients provided by the Peninsula Regional Medical Center, Li and Holdai conducted a retrospective statistical analysis to investigate whether the type of the first cancer affects the occurrence time and type of the second primary cancer.

Diabetes is a serious worldwide epidemic that affects a growing portion of the population. While the most common method for testing blood glucose levels involves finger pricking, it is painful and inconvenient for patients. The authors test a non-invasive method to measure glucose levels from diabetic patients, and investigate whether the method is clinically accurate and universally applicable.

Cuisine with hot chili peppers can be tasty, but sometimes painful to consume because of the burning sensations caused by the capsaicin molecule. The authors wanted to find the palate reliever that decreases the burning sensation of capsaicin the most by testing water, soft drink, olive oil, milk, and ice-cream as possible candidates. The authors hypothesized that olive oil would be the best palate reliever as it is non-polar like the capsaicin molecule. The authors surveyed 12 panelists with low, medium, and high spice tolerances and found that across all levels of spice tolerance, milk and ice-cream were the best palate relievers and soft drink the worst.

Cross country is a popular sport in the U.S. Both athletes and coaches are interested in the factors that make runners successful. In this study, the authors explore the relationship between runners' physical attributes and their race performance.

Coronary heart disease (CHD) is a global disease that causes fatal buildup of plaque in the arteries. Currently stents are placed in the artery for many patients with CHD to support proper blood flow. Here, the authors build a system to explore how the shape of the stent affects blood flow rate, a finding that can help optimize stents for patients.