In this study, the authors looked at a proto-oncogene, KRAS, and searched for molecules that are predicted to be able to bind to the inactive form of KRAS. They found that a modified version of Irbesartan, a derivative of benzimidazole, showed the best binding to inactive KRAS.
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Novel biaryl imines and amines as potential competitive inhibitors of dihydropteroate synthase
In this study, the authors design a series of new biaryl small molecules to target and block the binding pocket of the enzyme dihydropteroate synthase, which is important for prokaryotic biosynthesis of folic acid and could serve as better antimicrobial compounds.
Read More...The effects of food type on mediator-less microbial fuel cell electricity output
The authors look at how different food types impact the ability of bacteria to produce electricity.
Read More...Environmentally-friendly graphene conductive ink using graphene powder, polystyrene, and waste oil
In this article, the authors propose an effective, environmentally-friendly method of producing conductive ink using expired waste oil, polystyrene, and graphene.
Read More...One-step photochemical crosslinking of native proteins is feasible in tyrosine-rich bovine serum albumin
In this study, the authors develop a new hydrogel using photochemical crosslinking with bovine serum albumin and methylene blue. They find that this new hydrogel has some useful applications!
Read More...Converting SiO2 wafers to hydrophobic using chlorotrimethylsilane
Semiconductors are the center of the fourth industrial revolution as they are key components for all electronics. Exposed wafers made of silicon (Si), which can easily oxidize, convert to silicon dioxide (SiO2). The surface of SiO2 wafers consists of many Si-OH bonds, allowing them to easily bond with water, resulting in a “wet” or hydrophilic condition. We sought to determine a way to modify the surface of SiO2 wafers to become hydrophobic to ensure safe wet cleaning.
Read More...Use of drone with sodium hydroxide carriers to absorb carbon dioxide from ambient air
In this study, the authors address the current climate concern of high CO2 levels by testing solid forms of hydroxide for CO2 reduction and designing a drone to fly it in ambient air!
Read More...Combined Progestin-Estrogenic Contraceptive Pills May Promote Growth in Crop-Plants
Ethinyl estradiol and progestin norgestrel are commonly present in contraceptive tablets and it is unknown how they affect the environment. In this study, the authors investigate the role that ethinyl estradiol and progestin norgestrel have on the growth of flowering plants. The percentage germination, embryonic and adventitious tissue proliferation, root length, and shoot length were measured in V. radiata and T. aestivum treated with each compound and results demonstrate that ethinyl estradiol and progestin norgestrel can induce growth in both plants at certain concentrations. These findings have important implications as societal use of chemicals increases and more make their way into the environment.
Read More...Use of yogurt bacteria as a model surrogate to compare household cleaning solutions
While resources on the safety of household cleaning products are plentiful, measures of efficacy of these cleaning chemicals against bacteria and viruses remain without standardization in the consumer market. The COVID pandemic has exasperated this knowledge gap, stoking the growth of misinformation and misuse surrounding household cleaning chemicals. Arriving at a time dire for sanitization standardization, the authors of this paper have created a quantifying framework for consumers by comparing a wide range of household cleaning products in their efficacy against bacteria generated by a safe and easily replicable yogurt model.
Read More...Novel environmentally friendly approach to wastewater treatment eliminates aluminum sulfate and chlorination
The authors tested environmentally-friendly alternatives to wastewater treatment chemicals, including activated charcoal for filtration and citrus peels for preventing bacterial growth.
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