The authors use HF-1, an herbal formation, on bone marrow derived cells as well as breast cancer cells to assess HF-1's ability to prevent tumorigenesis. As metastasis requires coordination of multiple cells in the tumor microenvironment, their findings that HF-1 augments cytokine expression such as VEGF & TGF-B show that HF-1 has potential application to therapeutics.

Algal overgrowth often threatens to clog irrigation pipes and drinking water lines when left unchecked, as well as releasing possible toxins that threaten plant and human health. It is thus important to find natural, non-harmful agents that can decrease algal growth without threatening the health of plants and humans. In this paper, the authors test the efficacy of barely extract in either liquid or pellet form in decreasing algal growth. While their results were inconclusive, the experimental set-up allows them to investigate a wider range of agents as anti-algal treatments that could potentially be adopted on a wider scale.

With growing demands for ethanol, many researchers are turning to Panicum virgatum (switchgrass) as a feedstock of cellulosic ethanol. In this study, Ferris and Gillan examine the germination, biomass, nitrogen, survival, and chlorophyll absorbance of two switchgrass cultivars of grown in competition with Bromus inermis (smooth brome) with two varying levels of nitrogen fertilizer. Results presented indicate that during establishment, competition from other species has a greater effect than nitrogen fertilizer.

The authors investigated an important parasite-host relationship between the raccoon roundworm and the raccoon to understand how parasite prevalence is affected by location. They found that the parasite infection was more prevalent in raccoons found closer to human dwellings, though the number of roundworm eggs was not significantly different. These results are important human health, since roundworm infection is lethal to humans and can be transmitted from raccoons to humans - the authors suggest that more research into this parasite and awareness of its prevalence is needed to prevent disease.

Regenerative medicine has become a mainstay in recent times, and employing stem cells to treat several degenerative, inflammatory conditions has resulted in very promising outcomes. These forms of cell-based therapies are novel approaches to existing treatment modalities. In this study, the authors compared the concentrations of the cytokines PDGF, IL-8, and VEGF between conditioned and spent media of mesenchymal stem cells (MSCs) to evaluate their potential therapeutic properties for wound healing in inflammatory conditions. They hypothesized that conditioned media contains higher concentrations of wound healing cytokines compared to spent media. The authors found that while IL-8 and VEGF were present in highest concentrations in conditioned media, PDGF was present in maximal amounts in spent media.

Environment affects the progression of life, especially at the cellular level. This study investigates multiple 3-dimensional growth environments, also known as scaffolds or hydrogels, and their effect on the growth of a type of cells called fibroblasts. These results suggest that a scaffold made of collagen and polyethylene glycol are favorable for cell growth. This research is useful for developing implantable devices to aid wound healing.

The purpose of this investigation is to develop a hydrogel to aid skin regeneration by creating an extracellular matrix for fibroblast growth with antibacterial and infection-detection properties. Authors developed two natural hydrogels based on pectin and potato peels and characterized the gels for fibroblast compatibility through rheology, scanning electron microscopy, swelling, degradation, and cell cytotoxicity assays. Overall, this experiment fabricated various hydrogels capable of acting as skin substitutes and counteracting infections to facilitate wound healing. Following further testing and validation, these hydrogels could help alleviate the 13-billion-dollar financial burden of foot ulcer treatment.

In this study, the authors investigate the suitability of using bacterial cellulose as a scaffold for cell transplants. Interestingly, this cellulose is a can be found in the discard from a symbiotic culture of bacteria and yeast (SCOBY) used to make kombucha.

Ethinyl estradiol and progestin norgestrel are commonly present in contraceptive tablets and it is unknown how they affect the environment. In this study, the authors investigate the role that ethinyl estradiol and progestin norgestrel have on the growth of flowering plants. The percentage germination, embryonic and adventitious tissue proliferation, root length, and shoot length were measured in V. radiata and T. aestivum treated with each compound and results demonstrate that ethinyl estradiol and progestin norgestrel can induce growth in both plants at certain concentrations. These findings have important implications as societal use of chemicals increases and more make their way into the environment.

Berberine, a natural product alkaloid, has been shown to exert biological activity via in situ production of singlet oxygen when photo irradiated. Berberine utilizes singlet oxygen in its putative mechanism of action, wherein it forms an activated complex with DNA and photosensitizes triplet oxygen to singlet oxygen to specifically oxidize guanine residues, thereby halting cell replication and leading to cell death. This has potential application in photodynamic therapy, alongside other such compounds which also act as photosensitizers and produce singlet oxygen in situ. The quantification of singlet oxygen in various photosensitizers, including berberine, is essential for determining their photosensitizer efficiencies. We postulated that the singlet oxygen produced by photoirradiation of berberine would be superior in terms of singlet oxygen production to the aforementioned photosensitizers when irradiated with UV light, but inferior under visible light conditions, due to its strong absorbance of UV wavelengths.