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Temperature and Precipitation Responses to a Stratospheric Aerosol Geoengineering Experiment Using the Community Climate System Model 4

Anderson et al. | Aug 19, 2014

Temperature and Precipitation Responses to a Stratospheric Aerosol Geoengineering Experiment Using the Community Climate System Model 4

We are changing our environment with steadily increasing carbon dioxide emissions, but we might be able to help. The authors here use a computer program called Community Climate System Model 4 to predict the effects of spraying small particles into the atmosphere to reflect away some of the sun's rays. The software predicts that this could reduce the amount of energy the Earth's atmosphere absorbs and may limit but will not completely counteract our carbon dioxide production.

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Evaluating Biomarkers and Treatments for Acute Kidney Injury in a Zebrafish Model

Mathew et al. | Aug 11, 2019

Evaluating Biomarkers and Treatments for Acute Kidney Injury in a Zebrafish Model

Coronary Artery Disease (CAD) is the leading cause of death in the United States, and 81% of Acute Kidney Injury (AKI) patients in the renal fibrosis stage later develop CAD. In this study, Mathew and Joykutty aimed to create a cost-effective strategy to treat AKI and thus prevent CAD using a model of the zebrafish, Danio rerio. They first tested whether AKI is induced in Danio rerio upon exposure to environmental toxins, then evaluated nitrotyrosine as an early biomarker for toxin-induced AKI. Finally, they evaluated 4 treatments of renal fibrosis, the last stage of AKI, and found that the compound SB431542 was the most effective treatment (reduced fibrosis by 99.97%). Their approach to treating AKI patients, and potentially prevent CAD, is economically feasible for translation into the clinic in both developing and developed countries.

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A novel filtration model for microplastics using natural oils and its application to the environment

Park et al. | Jun 27, 2022

A novel filtration model for microplastics using natural oils and its application to the environment

Recognizing the need for a method to filter microplastics from polluted water the authors sought to use nonpolar solvents, palm oil and palm kernel oil, to filter microplastics out of model seawater. By relying on the separation of polar and nonpolar solvents followed by freezing the nonpolar solvent, they reported that microplastics could be extracted with percentages ranging from 96.2% to 94.2%. They also provided an estimation to use this method as part of container ships to clean the Pacific Ocean of microplastics.

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Comparing the Effects of Different Natural Products on Reducing Tumor Growth in a Drosophila Model

Ganesh et al. | May 31, 2020

Comparing the Effects of Different Natural Products on Reducing Tumor Growth in a <i>Drosophila</i> Model

In this work, the authors compared the effects of common natural products, including sesame, cinnamon, garlic, moringa and turmeric on tumor growth in Drosophila eyes. The data showed that these natural products cannot be used to reduce tumor growth once it has completely formed. However, the data suggested that some natural products can reduce cancer cell growth when tumors are treated early.

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Fractal dimensions of crumpled paper

Zhou et al. | Aug 10, 2023

Fractal dimensions of crumpled paper
Image credit: Richard Dykes

Here, beginning from an interest in fractals, infinitely complex shapes. The authors investigated the fractal object that results from crumpling a sheet of paper. They determined its fractal dimension using continuous Chi-squared analysis, thereby testing and validating their model against the more conventional least squares analysis.

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Phospholipase A2 increases the sensitivity of doxorubicin induced cell death in 3D breast cancer cell models

Lee et al. | Mar 30, 2022

Phospholipase A2 increases the sensitivity of doxorubicin induced cell death in 3D breast cancer cell models

Inefficient penetration of cancer drugs into the interior of the three-dimensional (3D) tumor tissue limits drugs' delivery. The authors hypothesized that the addition of phospholipase A2 (PLA2) would increase the permeability of the drug doxorubicin for efficient drug penetration. They found that 1 mM PLA2 had the highest permeability. Increased efficiency in drug delivery would allow lower concentrations of drugs to be used, minimizing damage to normal cells.

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The Effects of Ezetimibe on Triglyceride and Alanine Transaminase Reduction in Drosophila Melanogaster Model of Nonalcoholic Fatty Liver Disease (NAFLD)

Dania et al. | Apr 30, 2020

The Effects of Ezetimibe on Triglyceride and Alanine Transaminase Reduction in <i>Drosophila Melanogaster</i> Model of Nonalcoholic Fatty Liver Disease (NAFLD)

Nonalcoholic Fatty Liver Disease (NAFLD) is a condition where a surplus of triglycerides or fat are present in the liver. In this study, ezetimibe, a cholesterol lowering drug, was used to treat flies modeling NAFLD. Compared to the coconut oil fed flies that were transferred to the control medium, the flies transferred to the control medium treated with ezetimibe showed a decrease in their triglyceride and alanine transaminase level.

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Effect of Natural Compounds Curcumin and Nicotinamide on α-synuclein Accumulation in a C. elegans Model of Parkinson’s Disease

Mehrotra et al. | Jan 29, 2018

Effect of Natural Compounds Curcumin and Nicotinamide on α-synuclein Accumulation in a C. elegans Model of Parkinson’s Disease

Parkinson's disease is a neurodegenerative disorder that affects over 10 million people worldwide. It is caused by destruction of dopamine-producing neurons, which results in severe motor and movement symptoms. In this study, the authors investigated the anti-Parkinsonian effects of two natural compounds curcumin and nicotinamide using C. elegans as a model organism.

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Modeling the effects of acid rain on bacterial growth

Shah et al. | Nov 17, 2020

Modeling the effects of acid rain on bacterial growth

Acid rain has caused devastating decreases in ecosystems across the globe. To mimic the effect of acid rain on the environment, the authors analyzed the growth of gram-negative (Escherichia coli) and gram-positive (Staphylococcus epidermidis) bacteria in agar solutions with different pH levels. Results show that in a given acidic environment there was a significant decrease in bacterial growth with an increase in vinegar concentration in the agar, suggesting that bacterial growth is impacted by the pH of the environment. Therefore, increased levels of acid rain could potentially harm the ecosystem by altering bacterial growth.

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Comparative analysis of CO2 emissions of electric ride-hailing vehicles over conventional gasoline personal vehicles

Raman et al. | Jan 12, 2024

Comparative analysis of CO<sub>2</sub> emissions of electric ride-hailing vehicles over conventional gasoline personal vehicles
Image credit: Paul Hanaoka

While some believe that ride-hailing services offer reduced CO2 emissions compared to individual driving, studies have found that driving without passengers on ride-hailing trips or "deadheading" prevents this. Here, with a mathematical model, the authors investigated if the use of electric vehicles as ride-hailing vehicles could offer reduced CO2 emissions. They found that the improved vehicle efficiency and cleaner generation could in fact lower emissions compared to the use of personal gas vehicles.

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