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Alzheimer's disease is one of the leading causes of death in the United States and is characterized by neurodegeneration. Mishra et al. wanted to understand the role of two transport proteins, LRP1 and AQP4, in the neurodegeneration of Alzheimer's disease. They used a model organism for Alzheimer's disease, the nematode C. elegans, and genetic engineering to look at whether they would see a decrease in neurodegeneration if they increased the amount of these two transport proteins. They found that the best improvements were caused by increased expression of both transport proteins, with smaller improvements when just one of the proteins is overly expressed. Their work has important implications for how we understand neurodegeneration in Alzheimer's disease and what we can do to slow or prevent the progression of the disease.

In this study, the authors develop a new hydrogel using photochemical crosslinking with bovine serum albumin and methylene blue. They find that this new hydrogel has some useful applications!

In this study, the authors investigate the suitability of using bacterial cellulose as a scaffold for cell transplants. Interestingly, this cellulose is a can be found in the discard from a symbiotic culture of bacteria and yeast (SCOBY) used to make kombucha.

Environment affects the progression of life, especially at the cellular level. This study investigates multiple 3-dimensional growth environments, also known as scaffolds or hydrogels, and their effect on the growth of a type of cells called fibroblasts. These results suggest that a scaffold made of collagen and polyethylene glycol are favorable for cell growth. This research is useful for developing implantable devices to aid wound healing.

Irrespective of the final application of a molecule, synthetic accessibility is the rate-determining step in discovering and developing novel entities. However, synthetic complexity is challenging to quantify as a single metric, since it is a composite of several measurable metrics, some of which include cost, safety, and availability. Moreover, defining a single synthetic accessibility metric for both natural products and non-natural products poses yet another challenge given the structural distinctions between these two classes of compounds. Here, we propose a model for synthetic accessibility of all chemical compounds, inspired by the Central Limit Theorem, and devise a novel synthetic accessibility metric assessing the overall feasibility of making chemical compounds that has been fitted to a Gaussian distribution.

The authors looked at how a 3D bioprinter could be used to model the blood brain barrier.

Pay is a widely debated factor in workplace motivation, influencing both incentives and job satisfaction. This work analyzed employee reviews across various industries to examine the relationship between pay importance and job satisfaction. Findings suggest that job satisfaction decreases as the importance of pay increases, particularly in construction, food, and finance industries, as well as among entry-level and experienced workers, though the results were not statistically significant.

In this study, the authors explored whether students' test scores were significantly higher on online exams during the COVID-19 school lockdown when compared to those of the in-person exams before the lockdown.

In this report, Bhardwaj and Sharma tested whether placing specific plants indoors can reduce levels of indoor air pollution that can lead to lung-related illnesses. Using machine learning, they show that plants improved overall indoor air quality and reduced levels of particulate matter. They suggest that plant-based interventions coupled with sensors may be a useful long-term solution to reducing and maintaining indoor air pollution.

Microscopic beauty is hiding in common kitchen ingredients - even vanillin flavoring can be turned into mesmerizing artwork by crystallizing the vanillin and examining it under a polarizing microscope. Wang and Pang explore this hidden beauty by determining the optimal conditions to grow crystalline vanillin films and by creating computer simulations of chemical interactions between vanillin molecules.