Malaria is a major public health issue, especially in developing countries, and vector control is a major facet of malaria eradication efforts. Recently, sterile insect technique (SIT), or the release of sterile mosquitoes into the wild, has shown significant promise as a method of keeping vector populations under control. In this study, the authors investigate the Anopheles gambiae transglutaminase 3 protein (AgT3), which is essential to the mating of the Anopheles mosquito. They show that an active site mutation is able to abolish the activity of the AgT3 enzyme and propose it as a potential target for chemosterilant inhibitors.

Microbial agents reposnsible for respiratory infections are often carried in spittle, which means they can be easily transmitted. Here, the authors investigate how likely certain activities are to spread microbes carried in spittle. They also investigate whether eating certain types of food might reduce the spread of spittle-borne bacteria too.

In this study, the authors conducted a statistical investigation into the history of position-based racial segregation in the NFL. Specifically, they focused on the cornerback position, which they hypothesized would be occupied disproportionately by black players due to their historical stereotyping as more suitable for positions requiring extreme athletic ability. Using publicly available datasets on the demographics of NFL players over the past several decades, they confirmed their hypothesis that the cornerback position is skewed towards black players. They additionally discovered that, unlike in the quarterback position, this trend has shown no sign of decreasing over time.

The authors test the effectiveness of various cleaning agents on refrigerator shelves.

This paper presents findings on Carcharhinus leucas (bull shark) and Carcharhinus amblyrhynchos (grey reef shark) aggression towards humans at Beqa Adventure Divers in Shark Reef Marine Reserve, Fiji. We hypothesized that grey reef sharks would receive more prods than bull sharks because grey reef sharks are typically more aggressive than bull sharks. The results supported our hypothesis, as an individual grey reef shark received 2.44 prods on average per feed, while a bull shark had an average of 0.61. These findings are meaningful not only to the world’s general understanding of shark aggression, but also to human protection against grey reef sharks as well as public education on bull sharks and the conservation of the species.

For public health, drinking water should be free of bacterial contamination. The objective of this research is to identify the fate of bacteria if drinking water becomes contaminated and inform consumers on which water type enables the least bacteria to survive. We hypothesized that bottled mineral water would provide the most sufficient conditions for E. coli to survive. We found that if water becomes contaminated, the conditions offered by the three water types at room temperature allow E. coli to survive up to three days. At 72 hours, the bottled spring water had the highest average colony forming units (CFUs), with tap and mineral water CFU values statistically lower than spring water but not significantly different from each other. The findings of this research highlight the need of implementing accessible quality drinking water for the underserved population and for the regulation of water sources.

Economic disruptions and housing instabilities have for long propelled a homelessness epidemic among adults and youth in the United States. The COVID-19 pandemic has accelerated this phenomenon with a 2.2% increase in the number of homeless individuals and more than 70% of Americans fearing this outcome for themselves. This study aimed to analyze the perception of homelessness in two groups: Those who have previously experienced and overcome homelessness and those who are at-risk for experiencing the same. The study analyzed publicly available Reddit posts by people in both groups and found that at-risk individuals tended to associate primarily fearful emotions with the event, and those who had overcome homelessness tended to view the event in a negative context. These results may encourage the establishment of resources to support the currently homeless and help them transition into society, and services to help them cope with negative emotions, as negative attitudes have been shown to decrease life expectancy.

Glioblastoma Multiforme (GBM) is the most malignant brain tumor with the highest fraction of genome alterations (FGA), manifesting poor disease-free status (DFS) and overall survival (OS). We explored The Cancer Genome Atlas (TCGA) and cBioportal public dataset- Firehose legacy GBM to study DNA repair genes Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) and Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3 (ALKBH3). To test our hypothesis that these genes have correlations with FGA and can better determine prognosis and survival, we sorted the dataset to arrive at 254 patients. Analyzing using RStudio, both ASCC3 and ALKBH3 demonstrated hypomethylation in 82.3% and 61.8% of patients, respectively. Interestingly, low mRNA expression was observed in both these genes. We further conducted correlation tests between both methylation and mRNA expression of these genes with FGA. ASCC3 was found to be negatively correlated, while ALKBH3 was found to be positively correlated, potentially indicating contrasting dysregulation of these two genes. Prognostic analysis showed the following: ASCC3 hypomethylation is significant with DFS and high ASCC3 mRNA expression to be significant with OS, demonstrating ASCC3’s potential as disease prediction marker.

In this study, the authors created a survey to assess misconceptions and knowledge deficits regarding cardiovascular diseases exist among US adults and minors.

In this study, the authors identify new potential targets to treat advanced diffuse large B-cell lymphoma after treatment relapse and loss of CD19 expression.