Unsatisfactory hand hygiene leads to the spread of bacterial infections from person to person. To address this problem, the authors developed and tested the PeelTowel, an antibacterial and water-absorbing towel made of a combination of fruit peels and recycled paper waste.
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Combinatorial treatment by siNOTCH and retinoic acid decreases A172 brain cancer cell growth
Treatments inhibiting Notch signaling pathways have been explored by researchers as a new approach for the treatment of glioblastoma tumors, which is a fast-growing and aggressive brain tumor. Recently, retinoic acid (RA) therapy, which inhibits Notch signaling, has shown a promising effect on inhibiting glioblastoma progression. RA, which is a metabolite of vitamin A, is very important in embryonic cellular development, which includes the regulation of multiple developmental processes, such as brain neurogenesis. However, high doses of RA treatment caused many side effects such as headaches, nausea, redness around the injection site, or allergic reactions. Therefore, we hypothesized that a combination treatment of RA and siRNA targeting NOTCH1 (siNOTCH1), the essential gene that activates Notch signaling, would effectively inhibit brain cancer cell proliferation. The aim of the study was to determine whether inhibiting NOTCH1 would inhibit the growth of brain cancer cells by cell viability assay. We found that the combination treatment of siNOTCH1 and RA in low concentration effectively decreased the NOTCH1 expression level compared to the individual treatments. However, the combination treatment condition significantly decreased the number of live brain cancer cells only at a low concentration of RA. We anticipate that this novel combination treatment can provide a solution to the side effects of chemotherapy.
Read More...Variation in Caffeine Concentration Among Different Weight Loss Supplements Containing Green Tea and Green Coffee Extracts
Many weight loss supplements contain the stimulant caffeine, but do not disclose the amount. Here, authors measure and compare the amount of caffeine in different dietary supplements. This research gives consumers better understanding of the impact natural supplements may have on their health.
Read More...The Effect of Cooking Method on the Amount of Fat in an Egg
Fat can be chemically altered during cooking through a process called lipid oxidation, which can have a negative impact on health. In this study, the authors measured the extracted fat in raw, fried and hard-boiled eggs and found that cooking eggs to a higher temperature resulted in a lower amount of extracted fat, indicating a greater amount of oxidized fat.
Read More...Biofortification of Raphanus sativus through irrigation with Ca2+ solutions does not increase calcium content
This study is centered around developing biofortification methods: the authors test whether the amount of calcium available to growing crops translates into more calcium present in the crops.
Read More...Pediatric probiotic culture survival study in acidic pH using an in vitro model
In this study, the authors investigate the effects of acidity on the survival of commercial probiotic Lovebug bacterial strains.
Read More...Socio-economic factor impact on malnutrition in South Indian government school children
The authors look at malnutrition in children and how socio-economic factors impact this.
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