The authors analyze political endorsement patterns and impacts from the 2018 and 2020 midterm elections and find that such endorsements may be predictable based on the ideological and demographic factors of the endorser.
Read More...Who controls U.S. politics? An analysis of major political endorsements in U.S. midterm elections
The authors analyze political endorsement patterns and impacts from the 2018 and 2020 midterm elections and find that such endorsements may be predictable based on the ideological and demographic factors of the endorser.
Read More...Effects of vascular normalizing agents on immune marker expression in T cells, dendritic cells, and melanoma cells
Tertiary lymphoid structures (TLS) are lymph node-like structures that form at sites of inflammation, and their presence in cancer patients is predictive of a better clinical outcome. One significant obstacle to TLS formation is reduced immune cell infiltration into the tumor microenvironment (TME). Recent studies have shown that vasculature normalizing (VN) agents may override this defect to improve tissue perfusion and increased immune cell entry into the TME. However, their effects on immune cell and tumor cell phenotype remain understudied. Here the authors investigate whether treating tumor cells with VN would reduce their immunosuppressive phenotype and promote production of chemokine that recruit immune cells and foster TLS formation.
Read More...Sex differences in confidence and memory
In this work, the authors sought to provide an original experiment to investigate the conflict over whether males or females tend to exhibit greater accuracy or confidence in their memories. By using an online portal to obtain a convenience sample, the authors found that their results suggest that though males tend to be more confident regarding their memories, they may in fact remember fewer details. The authors suggest that these findings merit further research before making systematic changes regarding crime scene recall settings.
Read More...Evaluating TensorFlow image classification in classifying proton collision images for particle colliders
In this study the authors looked at developing a more efficient particle collision classification method with the goal of being able to more efficiently analyze particle trajectories from large-scale particle collisions without loss of accuracy.
Read More...Mismatch repair is not correlated with genomic alterations in glioblastoma patients
The authors looked at biomarkers in glioblastoma patients they hypothesized to be correlated with survival rate. Ultimately they did not find hMSH2 or hMSH6, genes involved in mismatch repair, to be significantly associated with outcomes related to increased survival.
Read More...DNA-SEnet: A convolutional neural network for classifying DNA-asthma associations
In this study, the authors developed a model named DNA Sequence Embedding Network (DNA-SEnet) to classify DNA-asthma associations using their genomic patterns.
Read More...TNF signaling pathway upregulation as a potential pharmaceutical target for cocaine-addicted individuals
In this article, the authors investigate the RNA expression differences between groups of chronic cocaine abusers and drug-free subjects.
Read More...Phytoplankton Plastid Proteomics: Cracking Open Diatoms to Understand Plastid Biochemistry Under Iron Limitation
In many areas of the world’s oceans, diatoms such as Thalassiosira pseudonana are limited in growth by the availability of iron (Fe), which is an essential nutrient for diatoms. The authors of this study examined if Fe-limitation makes a significant difference in the proteins expressed within the chloroplast, the power source for diatoms, utilizing a new plastid isolation technique specific to diatoms and completing 14 mass spectrometry experiments.
Read More...Genetic underpinnings of the sex bias in autism spectrum disorder
Here, seeking to identify a possible explanation for the more frequent diagnosis of autism spectrum disorder (ASD) in males than females, they sought to investigate a potential sex bias in the expression of ASD-associated genes. Based on their analysis, they identified 17 ASD-associated candidate genes that showed stronger collective sex-dependent expression.
Read More...Aberrant response to dexamethasone suppression test associated with inflammatory response in MDD patients
Major depressive disorder (MDD) is a prevalent mood disorder. The direct causes and biological mechanisms of depression still elude understanding, though genetic factors have been implicated. This study looked to identify the mechanism behind the aberrant response to the dexamethasone suppression test (DST) displayed by MDD patients, in which they display a lack of cortisol suppression. Analysis revealed several pro-inflammatory genes that were significant and differentially expressed between affected and non-affected groups in response to the DST. Looking at ways to decrease the inflammatory response could have implications for treatment and may explain why some people treated for depression still display symptoms or may lead researchers to different classes of drugs for treatment.
Read More...Search articles by title, author name, or tags