DegS is an integral inner membrane protein in E. coli that helps break down misfolded proteins. When it is mutated, there is a large increase in the production of outer membrane vesicles (OMVs), which are thought to play a role in pathogenesis. This study used mutant strains of uropathogenic E. coli (UPEC) to characterize the role of DegS and OMVs on UPEC virulence.

Minerals such as iron are essential for life, but too much of a good thing can be poisonous. Here the authors investigate the effect of iron concentrations on the growth of an aquatic plant and find that supplementing small amounts of iron can help, but adding too much can be bad for the plant. These results should help inform decisions on allowable iron concentrations in the environment, aquatic farming, and even home aquariums.

Malaria is a major public health issue, especially in developing countries, and vector control is a major facet of malaria eradication efforts. Recently, sterile insect technique (SIT), or the release of sterile mosquitoes into the wild, has shown significant promise as a method of keeping vector populations under control. In this study, the authors investigate the Anopheles gambiae transglutaminase 3 protein (AgT3), which is essential to the mating of the Anopheles mosquito. They show that an active site mutation is able to abolish the activity of the AgT3 enzyme and propose it as a potential target for chemosterilant inhibitors.

Many species of trees are distributed widely around the world, though not always in a way that makes immediate sense. The authors here use genetic information to help explain the geographic distribution of various conifer species throughout the world.